166例非四川省户籍HIV感染孕产妇孕期抗病毒治疗情况及影响因素  

Application of anti-HIV drugs during pregnancy in 166 HIV infected pregnant women without registered residence in Sichuan Province

作　　者：张莉莉 张刚 刘伟信 张燕 何丹 何朝华 岳岑 颜舵 王刚 ZHANG Lili;ZHANG Gang;LIU Weixin;ZHANG Yan;HE Dan;HE Chaohua;YUE Cen;YAN Duo;WANG Gang(Women and Children's Hospital of Sichuan Province.Obstetrics Department of Women and Children′s Hospital Affiliated to Chengdu Medical College,Chengdu 610041,Sichuan,China)

机构地区：[1]四川省妇幼保健院/成都医学院附属妇女儿童医院儿科,成都610045

出　　处：《中国艾滋病性病》2022年第11期1237-1240,共4页Chinese Journal of Aids & STD

基　　金：四川省科技计划重点研发项目(2020YFS0425)。

摘　　要：目的了解非四川省户籍HIV感染孕产妇孕期抗病毒治疗情况及影响因素。方法通过国家预防艾滋病、梅毒和乙肝母婴传播信息管理系统,收集2016年1月至2020年12月四川省分娩的166例非四川省户籍HIV感染产妇个案登记卡,对不同特征HIV感染产妇孕期抗病毒治疗情况进行描述,并采用多因素Logistic回归分析影响因素。结果166例HIV感染产妇平均年龄为(29.88±5.71)岁,文化程度以初中及以下(74.70%,124人)为主,职业以农民及农民工(42.17%,70人)为主。72.29%(120/166)的HIV感染孕产妇在孕期进行了抗病毒治疗。文化程度高中及以上(a OR=3.074,95%CI:1.402~10.513)、孕期确诊HIV感染(OR=1.201,95%CI:1.014~1.998)、孕早期及孕中期首次接受产检(孕早期a OR=1.380,95%CI:1.105~1.869;孕中期a OR=1.142,95%CI:1.028~1.553)、孕期随访次数多(1~4次:a OR=1.440,95%CI:1.108~1.829;≥5次:a OR=1.416,95%CI:1.182~1.912)、配偶文化程度高中及以上(a OR=1.335,95%CI:1.042~1.880)的孕期接受抗病毒治疗概率较高;产时或产后确诊HIV感染(a OR=0.512,95%CI:0.203~0.826)的孕期未接受抗病毒治疗的概率较高。结论非四川省户籍HIV感染孕产妇孕期抗病毒治疗比例相对较低。应重点加强对文化程度低、初婚、农民及农民工妇女的艾滋病母婴传播知识健康宣教,规范落实预防母婴传播干预服务,提高HIV感染孕产妇孕期抗病毒治疗率,减少艾滋病母婴传播的发生。Objective To investigate the situation and influencing factors of HIV-infected pregnant women without registered residence in Sichuan Province.Methods The data of 166 HIV-infected pregnant women delivered in Sichuan Province from Jan 2016 to Dec 2020 were collected through the national information management system of PMTCT.The anti-HIV treatment in pregnant women with different characteristics of HIV infection was described,and multivariate logistic regression was used to analyze the influencing factors.Results Among 166 HIV-infected mothers,the average age of 166 HIV-infected pregnant women were(29.88±5.71).124 cases(74.70%)were junior high school and below.70cases(42.17%)were farmers or migrant workers.120 cases(72.29%)received anti-HIV treatment during pregnancy.The probability of receiving anti-HIV treatment was high during pregnancy among the HIV-infected mothers with high school and above(OR=3.074,95%CI:1.402-10.513),confirmation of HIV infection during pregnancy(OR=1.201,95%CI:1.014-1.998)、first maternal examination in early pregnancy(OR=1.380,95%CI:1.105-1.869)and metaphase of pregnancy(OR=1.142,95%CI:1.028-1.553),more follow-up times during pregnancy(1-4 times;OR=1.440,95%CI:1.108-1.829;≥5times;OR=1.416,95%CI:1.182-1.912),spouse with high school and above education(OR=1.335,95%CI:1.042-1.880).The probability of not receiving anti-HIV treatment was high during pregnancy among the HIVinfected mothers with delivery and postpartum(OR=0.512,95%CI:0.203-0.826).Conclusions The proportion of anti-HIV treatment among HIV-infected pregnant women without registered residence in Sichuanp province was relatively low.It is essential to strengthen the health education to the lower education level,first marriage,farmers and migrant worker’s.We should improve the rate of anti-HIV treatment of HIV-infected pregnant women during pregnancy and standardize the implementation of mother-tochild transmission prevention intervention services to reduce the risk of mother to child transmission.

关 键 词：流动孕产妇 艾滋病病毒 抗病毒药物 

分 类 号：R373.9[医药卫生—病原生物学]