湖南省和重庆市部分孕产妇HCV感染及影响因素分析  

Prevalence of hepatitis C virus among pregnant women from provincial maternal and child health hospitals in Hunan and Chongqing

作　　者：孙贺 王岚[2] 吴颖岚 王潇滟[1] 钟其梅 杨敏[3] 高洁[3] 高群[1] 黄东旭 王前[1] 王爱玲[1] SUN He;WANG Lan;WU Yinglan;WANG Xiaoyan;ZHONG Qimei;YANG Min;GAO Jie;GAO Qun;HUANG Dongxu;WANG Qian;WANG Ailing(National Center for Women and Children's Health,Chinese Center for Disease Control and Prevention,Beijing 100081,China;Chongqing Health Center for Women and Children,Chongqing 400013;Hunan Provincial Maternal and Child Health Care Hospital,Changsha 410008)

机构地区：[1]中国疾病预防控制中心妇幼保健中心,北京100081 [2]重庆市妇幼保健院,重庆400013 [3]湖南省妇幼保健院,长沙410008

出　　处：《中国艾滋病性病》2022年第11期1241-1245,共5页Chinese Journal of Aids & STD

基　　金：中国疾病预防控制中心妇幼保健中心与世界卫生组织合作项目丙型肝炎病毒感染孕产妇母婴传播现况调查(202700588)。

摘　　要：目的了解在湖南省妇幼保健院和重庆市妇幼保健院入院分娩的孕产妇人群HCV的感染情况及相关影响因素。方法通过横断面调查的研究方法对2019年7月1日至2021年12月31日期间于湖南省妇幼保健院和重庆市妇幼保健院入院分娩的产妇进行流行病学调查。在研究地区妇幼保健机构内孕产保健科、产科、检验科和感染科等相关科室的病案管理信息系统收集调查相关信息。结果在上述两家妇幼保健院共收集符合条件的研究对象84814名,其中65人感染HCV,感染率为0.08%(95%CI:0.06%~0.10%),不同年龄组间HCV抗体阳性率差异有统计学意义(χ^(2)=38.10,P<0.001),且随年龄增加感染风险增加(Z=5.35,P<0.001)。不同梅毒合并感染状态(χ^(2)=111.37,P<0.001)、前置胎盘(Fisher检验P<0.001)、婴儿出生体重(F=4.15,P=0.04)与HCV抗体阳性率相关。多因素分析发现,与小于30岁的孕产妇相比,年龄超过35岁的孕产妇感染HCV的风险更高(OR=4.76,95%CI:2.51~9.05),与未感染梅毒的孕产妇相比,感染梅毒者检出HCV的风险更高(OR=14.68,95%CI:6.59~32.68)。结论在湖南省妇幼保健院和重庆市妇幼保健院入院分娩的孕产妇HCV感染率处于较低水平,但仍需要重视孕产妇HCV感染及其相关因素,关注梅毒等性传播疾病的合并感染。Objective To investigate the prevalence of hepatitis C virus and its related influencing factors among pregnant women in Hunan and Chongqing provincial maternal and child health hospitals.Methods A cross-sectional survey was conducted among parturient women in Hunan Provincial Maternal and Child Health Care Hospital and Chongqing Municipal Maternal and Child Health Care Hospital from July 1,2019,to December 31,2021.The related information was collected and investigated in the medical record management system of maternal and child health care departments,obstetrics departments,laboratory departments,and infection departments in maternal and child health care institutions in the study area.Results A total of 84814 eligible subjects were collected from the above two maternal and child health care hospitals,among whom 65 were infected with HCV,and the infection rate was 0.08%(95%CI:0.06%-0.10%).There were significant differences in HCV antibody positive rate among different age groups(χ^(2)=38.10,P<0.001),and the risk of infection increased with age(Z=5.35,P<0.001).Different syphilis co-infection statuses(χ^(2)=111.37,P<0.001),placenta previa(Fisher P<0.001)and infant birth weight(F=4.15,P=0.04)were associated with HCV antibody positive rate.Multivariate analysis showed that compared with pregnant women younger than 30 years old,pregnant women older than 35 years old had a higher risk of HCV infection(OR=4.76,95%CI:2.51-9.05),and compared with pregnant women without syphilis infection,pregnant women with syphilis infection had a higher risk of HCV detection(OR=14.68,95%CI:6.59-32.68).Conclusions The HCV infection rate of pregnant women in Hunan Provincial Maternal and Child Health Hospital and Chongqing Municipal Maternal and Child Health Hospital is low.However,paying attention to HCV infection,its related factors,and the co-infection of syphilis and other sexually transmitted diseases is still necessary.

关 键 词：丙型肝炎病毒 孕产妇 流行 

分 类 号：R512.6[医药卫生—内科学]