小剂量右美托咪定联合全身麻醉在胸腰椎骨折手术患者中的应用效果  

Application effects of low-dose Dexmedetomidine combined with general anesthesia in patients with thoracolumbar fracture surgeries

作　　者：路玉巧 LU Yuqiao(Department of Anesthesiology of Huixian City People’s Hospital,Xinxiang 453600 Henan,China)

机构地区：[1]辉县市人民医院麻醉科,河南新乡453600

出　　处：《中国民康医学》2022年第21期44-46,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:观察小剂量右美托咪定联合全身麻醉在胸腰椎骨折手术患者中的应用效果。方法:选取2019年5月至2021年3月该院收治的80例行经皮椎体后凸成形术治疗的胸腰椎骨折患者进行前瞻性研究,按照随机数字表法将其分为对照组(n=40)和观察组(n=40)。对照组采用常规剂量右美托咪定联合全身麻醉,观察组采用小剂量右美托咪定联合全身麻醉,比较两组麻醉效果、不同时刻[麻醉前(t)、右美托咪定给药后5 min(t)]血流动力学指标(收缩压、舒张压及心率)水平、苏醒时间和自主呼吸恢复时间。结果:观察麻醉总有效率为95.00%(38/40),高于对照组的80.00%(32/40),差异有统计学意义(P<0.05);t时,两组收缩压、舒张压和心率水平均低于t时,但观察组高于对照组,差异有统计学意义(P<0.05);观察组苏醒时间和自主呼吸恢复时间均短于对照组,差异有统计学意义(P<0.05)。结论:小剂量右美托咪定联合全身麻醉应用于胸腰椎骨折手术患者可提高麻醉总有效率,缩短苏醒时间和自主呼吸恢复时间,提高血流动力学指标水平,效果优于常规剂量右美托咪定联合全身麻醉。Objective:To observe application effects of low-dose Dexmedetomidine combined with general anesthesia in patients with thoracolumbar fracture surgeries.Methods:A prospective study was conducted on 80 patients with thoracolumbar fractures admitted to the hospital from May 2019 to March 2021.They were divided into control group (n=40) and observation group (n=40) according to the random number table method.The control group was treated with conventional dose Dexmedetomidine combined with general anesthesia,while the observation group was treated with low-dose Dexmedetomidine combined with general anesthesia.The anesthetic effects,the hemodynamic index levels (systolic blood pressure,diastolic blood pressure and heart rate) levels at different times[before anesthesia (t),5 min after Dexmedetomidine administration (t)],the recovery time,and the spontaneous breathing recovery time were compared between the two groups.Results:The total effective rate of anesthesia in the observation group was 95.00%(38/40),which was higher than 80.00%(32/40) in the control group,and the difference was statistically signi?cant (P<0.05).At t,the systolic blood pressure,diastolic blood pressure and heart rate of the two groups were lower than those at t,but those of the observation group were higher than those of the control group,and the differences were statistically signi?cant (P<0.05).Further,the recovery time and the spontaneous breathing recovery time of the observation group were shorter than those of the control group,and the differences were statistically signi?cant (P<0.05).Conclusions:Low-dose Dexmedetomidine combined with general anesthesia can improve the total effective rate of anesthesia,shorten the recovery time and the spontaneous breathing recovery time,and improve the levels of hemodynamic indexes in the patients undergoing thoracolumbar fracture surgeries.Moreover,it is superior to conventional dose Dexmedetomidine combined with general anesthesia.

关 键 词：右美托咪定 胸腰椎骨折 经皮椎体后凸成形术 全身麻醉 血流动力学 苏醒过程 

分 类 号：R614[医药卫生—麻醉学]