miRNA在肠道病毒A71型与宿主细胞互作中的研究进展  

Progress in studies on the role of miRNA in enterovirus-A71—host cell interaction

作　　者：刘厚广[1] 任晴 孙萍萍 谢广成[2] Liu Houguang;Ren Qing;Sun Pingping;Xie Guangcheng(The Third Hospital of Xiamen,Xiamen 361100,China;Chengde Medical College,Chengde 067000,China)

机构地区：[1]厦门市第三医院,厦门361100 [2]承德医学院,承德067000

出　　处：《中华实验和临床病毒学杂志》2022年第5期615-619,共5页Chinese Journal of Experimental and Clinical Virology

基　　金：国家自然科学基金(81702008);河北省自然科学基金(H2018406024);承德医学院重大项目科研专项(KY2020002);河北省科技厅"技术创新引导专项-科技工作会商"项目;河北省高校重点学科(冀教高(2013)4号)。

摘　　要：肠道病毒A71型(enterovirus-A71,EV-A71)感染引起的手足口病(hand,foot,and mouth disease,HFMD)给婴幼儿身心健康带来巨大威胁,明确EV-A71的致病机制能够为EV-A71的防控提供科学依据。miRNA作为一类非编码RNA,通过靶向结合mRNA控制蛋白表达进而调控宿主细胞的多个生物过程,同时也参与病毒与宿主细胞的互作过程。本文主要从miRNA的生成、EV-A71感染宿主细胞后引起的miRNA表达谱改变、miRNA靶向EV-A71基因组和宿主基因调控EV-A71复制、宿主细胞抗EV-A71的天然免疫应答、细胞凋亡等方面进行综述,以期为进一步明确miRNA在EV-A71与宿主细胞互作和EV-A71致病机制中的作用提供科学依据。Hand,foot,and mouth disease(HFMD)caused by enterovirus-A71(EV-A71)has posed heavy disease and economic burdens to young children under 5 years of age and families.Elucidating the pathogenesis of EV-A71 will provide better evidence for prevention and control for EV-A71 infection.miRNAs are a class of non-coding RNA that regulate many biological processes of host cells through manipulating mRNA translation to control the protein levels by direct binding to mRNA,meanwhile,participating the virus-host cell interaction.Here,we mainly review the current knowledge on the biogenesis of miRNA,alterations of miRNA profiles induced by EV-A71,regulation of EV-A71 replication,anti-EV-A71 innate immunity and apoptosis by miRNA direct binding EV-A71 genome or host genes.All these will facilitate understanding the role of miRNA in EV-A71-host cell interaction and pathogenesis of disease caused by EV-A71.

关 键 词：MIRNA 肠道病毒A71型 病原体 宿主 相互作用 

分 类 号：R373.2[医药卫生—病原生物学]