中医药治疗肌少症的临床应用及治疗机制初探  

A preliminary investigation on clinical application and therapeutic mechanism of traditional Chinese medicine in treatment of sarcopenia

作　　者：张禹杰 方淑蓓 岑俊[3] 元唯安[1] ZHANG Yujie;FANG Shubei;CEN Jun;YUAN Wei’an(Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Shanghai Centre of Biomedicine Development,Shanghai 201203,China;Shanghai Construction Group Hospital,Shanghai 200083,China)

机构地区：[1]上海中医药大学附属曙光医院,上海201203 [2]上海市生物医药科技发展中心,上海201203 [3]上海建工医院,上海200083

出　　处：《上海中医药杂志》2022年第12期16-22,共7页Shanghai Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81403414);上海市卫健委临床研究专项(201940063);上海市“科技创新行动计划”生物医药科技支撑专项(20S21902100);上海申康医院发展中心“市级医院医企协同临床试验管理项目”(20CR4003B);上海市卫计委“杏林新星”项目(ZYSNXD011-RC-XLXX-20130049);上海市教委中西医结合-中成药临床评价平台项目(A1-U21-205-0103)。

摘　　要：肌少症被定义为老年人骨骼肌质量、力量和功能的进行性下降,伴随着身体虚弱、功能残疾、跌倒、住院和死亡,并且由于预期寿命的增加和全球老年人口的增长,本病正在成为一种主要的老年疾病。中医药疗法治疗肌少症具有独特优势。基于传统中医理论及国内外与肌少症相关的文献研究发现,采用中药、功法、针刺、推拿等治疗肌少症取得了一定的进展,但具体机制研究相对较少。总体而言,中医药对肌少症的研究还处于早期阶段,还需要开展高质量临床循证研究及基础研究,以提升中医药在肌少症防治中的作用。Sarcopenia is defined as a progressive decline in skeletal muscle mass,strength and function in the elderly,accompanied by an increased risk of physical frailty,functional disability,falls,hospitalization and death.With the global rise in life expectancy and the growth of the geriatric population,sarcopenia is becoming a major geriatric disorder.Based on the theory of Traditional Chinese Medicine(TCM)and original literature and reviews in the field,TCM has unique advantages for the treatment of sarcopenia which has made some progress from the aspects of traditional Chinese herbal medicine,traditional Chinese exercises,acupuncture,and Tuina.However,the specific mechanism needs further study.Overall,as the TCM research on sarcopenia is still at an early stage,high-quality clinical evidence-based research and fundamental research are needed to enhance the role of TCM in the prevention and treatment of sarcopenia.

关 键 词：肌少症 痿证 中医药疗法 临床应用 作用机制 研究进展 

分 类 号：R274.9[医药卫生—中西医结合]