2019-2021年泰州市中学新生结核潜伏感染现况及影响因素  

Status and influencing factors of latent tuberculosis infection among middle school students in Taizhou from 2019 to 2021

作　　者：王文瑾 刘巧[2] 缪昌东 陈静娟[3] 王展 竺丽梅[2] 陆伟 WANG Wen-jin;LIU Qiao;MIAO Chang-dong;CHEN Jing-juan;WANGZhan;ZHU Li-mei;LU Wei(Department of Epidemiology,School of Public Health,Nanjing Medical University,Nanjing211166,China;Institute of Chronic Infectious Diseases,Jiangsu Provincial Center for Disease Control and Prevention,Nanjing 210009,China;Department of Chronic Infectious Disease Control,Taizhou Center for Disease Control and Prevention,Taizhou 225300,China)

机构地区：[1]南京医科大学公共卫生学院流行病学系,南京211166 [2]江苏省疾病预防控制中心慢性传染病防制所,南京210009 [3]泰州市疾病预防控制中心慢性传染病防制科,泰州225300

出　　处：《中华疾病控制杂志》2022年第11期1264-1270,共7页Chinese Journal of Disease Control & Prevention

基　　金：国家自然科学基金(82003516);江苏省卫生健康委科研项目(ZD2021052,ZDA2020022,M2020020)。

摘　　要：目的 描述江苏省泰州市2019―2021年中学新生的结核潜伏感染现况,分析中学新生结核潜伏感染影响因素,为学校肺结核防控工作提供参考依据。方法 收集入学新生体检资料和结核菌素皮肤试验(tuberculin skin test,TST)结果,问卷收集与肺结核相关的个体特征,采用logistic回归分析模型分析潜伏感染相关影响因素。结果 研究共纳入泰州市18所中学13~18岁中学新生23 910人,其结核潜伏感染率为5.675%。多因素结果显示,高中生(aOR=1.569,95%CI:1.083~2.273,P=0.017)、18.5 kg/m^(2)≤BMI≤23.9 kg/m^(2)(aOR=1.415,95%CI:1.196~1.674,P<0.001)、BMI>23.9 kg/m^(2)(aOR=1.643,95%CI:1.358~1.988,P<0.001)、既往有结核病史(aOR=5.026,95%CI:2.264~11.155,P<0.001)是结核潜伏感染的危险因素。结论 增加户外运动锻炼时间,适当减压,提高机体免疫力,同时平衡膳食营养,以保持合适的BMI,是预防学生结核潜伏感染的有效途径。Objective To describe the prevalence of latent tuberculosis infection and analyze the influencing factors of latent tuberculosis infection among middle school freshmen from 2019 to 2021 in Taizhou City,Jiangsu Province,and to provide a reference for tuberculosis prevention and control in school.Methods The physical examination data and tuberculin skin test(TST) results of freshmen were collected,and the risk factors related to latent tuberculosis infection were collected by questionnaire.Logistic regression analysis model was used to analyze the data.Results A total of 23 910 participants aged 13-18 years old were included.The overall latent tuberculosis infection rate of tuberculosis among middle school students in Taizhou was 5.675%.Multivariate analysis results showed that senior high school students(aOR=1.569,95% CI:1.083-2.273,P=0.017),18.5 kg/m^(2)≤BMI≤23.9 kg/m^(2)(aOR=1.415,95% CI:1.196-1.674,P23.9 kg/m^(2)(aOR=1.643,95% CI:1.358-1.988,P<0.001),previous tuberculosis(aOR=5.026,95% CI:2.264-11.155,P<0.001) were the risk factors of latent tuberculosis infection.Conclusions Effective ways to prevent latent tuberculosis infection in middle school students include increasing outdoor exercise time,reducing stress appropriately,improving body immunity,and balancing diet nutrition to maintain proper BMI.

关 键 词：肺结核 中学新生 潜伏感染 结核菌素皮肤试验 

分 类 号：R51[医药卫生—内科学] R181.3[医药卫生—临床医学]