50 Hz工频电磁场致职业暴露人群短时记忆力降低与外周血中Aβ_(1-42)蛋白浓度关系的研究  

Study on the relationship between reduced short-term memory and peripheral blood Aβ_(1-42) protein concentration in occupationally people who were exposed to 50 Hz power frequency electromagnetic field

作　　者：边洪英[1] 张尧[2] 王艳[2] 董一文[1] 叶萌[1] BIAN Hong-ying;ZHANG Yao;WANG Yan;DONG Yi-wen;YE Meng(Department of Occupational Epidemiology and Risk Assessment,National Institute of Occupational Health and Poison Control,Chinese Center for Disease Control and Prevention,Beijing 100050,China;Sichuan Electric Power Hospital,Industrial Sanitation Station,Chengdu 61001l,China)

机构地区：[1]中国疾病预防控制中心职业卫生与中毒控制所职业流行病与风险评估研究室,北京100050 [2]四川电力医院工业卫生站,成都610011

出　　处：《中华疾病控制杂志》2022年第11期1326-1331,共6页Chinese Journal of Disease Control & Prevention

基　　金：中国疾病预防控制中心职业卫生与中毒控制所青年基金项目(2016PJ03);职业健康风险评估与国家职业卫生标准制定项目(131031109000160004)。

摘　　要：目的 研究50 Hz工频电磁场致职业暴露人群短时记忆力降低与外周血中Aβ_(1-42)(beta-amyloid peptide 1-42)蛋白浓度的关系。方法 选取51名火电厂电气运行人员为暴露组,26名同厂行政办公人员为对照组,两组人员均进行短时记忆力测试,同时测定外周血中Aβ_(1-42)蛋白浓度,比较两组中相关指标的差异及相关性。结果 暴露组8 h时间加权平均电场强度为1.690 kV/m,磁场强度为4.578μT。对照组8 h时间加权平均电场强度为0.008 kV/m,磁场强度为0.026μT。两组人员数字跨度得分暴露组低于对照组(t=3.702,P<0.001);暴露组失眠出现率(15.69%)和记忆力减退出现率(21.57%)均高于对照组(均有P<0.05);三项情感状态指标得分暴露组低于对照组:愤怒-敌意(t=2.239,P=0.028)、疲劳-惰性(t=2.024,P=0.047)、困惑-迷茫(t=2.489,P=0.015);外周血中Aβ_(1-42)蛋白浓度(pg/mL)暴露组高于对照组(t=-2.414,P=0.018)。数字跨度得分与Aβ_(1-42)蛋白浓度的变化并未发现相关关系(r=-0.173,P=0.133)。结论 50 Hz工频电磁场可致职业人群短时记忆力损伤,并引起外周血中Aβ_(1-42)蛋白浓度变化,但两者之间是否存在因果关系尚需进一步研究确定。Objective To study the relationship between reduced short-term memory and peripheral blood Aβ_(1-42) protein concentration induced by a 50 Hz power frequency electromagnetic field.Methods Fifty-one thermal power plant electrical operators were selected as the exposure group,and twenty-six administrative staffs of the same plant were selected as the control group.Both groups were tested for short-term memory,and the concentration of Aβ_(1-42) protein in peripheral blood was measured simultaneously.The correlation between the two groups was compared.Results The 8 h time-weighted average intensity of the exposed group was 1.690 kV/m,and the magnetic field intensity was 4.578 μT.In the control group,the average electric field strength was 0.008 kV/m,and the magnetic field strength was 0.026 μT for 8 h time-weighted average electric field intensity.The digit span score of the two groups in the exposed group was significantly lower than that in the control group(t=3.702,P<0.001);the incidence of autonomic symptoms of insomnia(15.69%) and memory loss(21.57%) in the exposed group was significantly higher than the control group(all P<0.05);the scores of three emotional state indicators in the exposed group were significantly lower than those in the control group,which incllding anger-hostility(t=2.239,P=0.028),fatigue-inert(t=2.024,P=0.047),and confusion-confusion(t=2.489,P=0.015);Aβ_(1-42) protein concentration in peripheral blood(pg/mL) with significantly higher in exposure group when compared to the control group(t=-2.414,P=0.018).No correlation was found between digital span scores and changes in Aβ_(1-42) protein concentration(r=-0.173,P=0.133).Conclusions 50 Hz power frequency electromagnetic field can cause short-term memory impairment in the occupational population and change the concentration of Aβ_(1-42) protein in peripheral blood.However,the causal relationship between them needs further study.

关 键 词：工频电磁场 学习记忆力 Aβ_(1-42)蛋白 

分 类 号：R135[医药卫生—劳动卫生] R181[医药卫生—公共卫生与预防医学]