老年与非老年起病系统性红斑狼疮患者临床特点的比较  

Comparison of clinical characteristics between senile and non-senile patients with systemic lupus erythematosus

作　　者：王许娜[1] 李楠[1] 王永峰[1] 王春燕[2] 贺付成[1] WANG Xuna;LI Nan;WANG Yongfeng;WANG Chunyan;HE Fucheng(Department of Clinical laboratory,the First Affliated Hospital of Zheng Zhou University,Key Laboratory of Laboratory Medicine of Henan Province,Zhengzhou 450052;Laboratory of Nephropathy,The First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第一附属医院检验科,河南省检验医学重点实验室,450052 [2]郑州大学第一附属医院肾病实验室,450052

出　　处：《中国老年保健医学》2022年第5期94-96,共3页Chinese Journal of Geriatric Care

摘　　要：目的 探讨老年发病系统性红斑狼疮(SLE)患者的临床特点。方法 回顾性分析我院2017年1月至2021年3月住院的63例老年SLE患者,选取同期住院的270例非老年狼疮患者作为对照组进行比较。结果 333例SLE患者的男女比例为1:7.65,老年患者占所有同期SLE患者的18.9%。老年组与非老年组相比,老年组的男女比例(1:3.2)较高;老年组男性病死率较高,并发症多;血小板减少、CRP升高、人血白蛋白降低较非老年SLE组多见,抗核抗体和抗Sm抗体阳性率较非老年组低。老年组患者WBC降低和血小板降低的发生率均高于非老年组,补体C3降低的发生率和抗核小体抗体及抗ds-DNA抗体的阳性率均低于非老年组,差异均有统计学意义(P<0.05)。红细胞沉降率(ESR)升高、补体C4降低的发生率,老年组和非老年组无统计学意义(P>0.05)。结论 老年发病的SLE患者与非老年发病的SLE患者的临床表现存在多种差异,老年SLE患者有的临床症状不典型,特异性免疫指标检出率较低,临床上应提高警惕,避免漏诊。Objective To investigate the characteristics of serum autoantibodies in senile patients with systemic lupus erythematosus(SLE). Methods A retrospective analysis was performed on 63 senile patients with SLE who were hospitalized in our hospital from January 2017 to March 2021,and 270 non-senile patients with SLE who were hospitalized during the same period were selected as the control group for comparison. Results The male to female ratio of 333 SLE patients was 1:7.65,the senile patients accounted for 18.9% of all the patients with SLE in the same period. The ratio of male to female in the senile group was higher than that in the non-senile group(1:3.2), the fatality rate and complications were higher in the senile group. Thrombocytopenia, increased CRP and decreased serum albumin were more common than those in the control group.The positive rates of anti-nuclear antibody and anti-Sm antibody were lower than those in the control group. The incidence of decreased WBC and thrombocytopenia in the senile group was higher than that in the non-senile group, the incidence of decreased complement C3 and the positive rate of anti-nucleosome antibody and anti-DS-DNA antibody were lower than that in the non-senile group, the differences were statistically significant(P<0.05). The incidence of decreased Hb, increased ESR and decreased complement C4,there was no significant difference between the senile group and the control group(P>0.05). Conclusion There are many differences in clinical manifestations between senile SLE patients and non-senile SLE patients.The clinical symptoms of senile SLE patients are characterized by atypical clinical symptoms and low detection rate of specific immune indicators.Clinical vigilance should be raised to avoid missed diagnosis.

关 键 词：系统性 红斑狼疮 临床特点 

分 类 号：R593.241[医药卫生—内科学]