中药方剂敏脱乐配合火针治疗慢性湿疹疗效观察及作用机制探讨  

Efficacy Observation and Mechanism Discussion of Mintuole Combined with Fire Acupuncture in Treating Chronic Eczema

作　　者：王胜强[1] 皮先明[2] 李凯[3] 詹黎[4] WANG Shengqiang;PI Xianming;LI Kai;ZHAN Li(Department of Dermatology/Integrated Traditional Chinese and Western Medicine,Central China Normal University Hospital,Wuhan 430079,Hubei,China;Department of Dermatology,Hubei Provincial Hospital of Traditional Chinese Medicine,Wuhan 430060,Hubei,China;Department of Dermatology,Wuhan Hospital of Traditional Chinese and Western Medicine,Wuhan 430022,Hubei,China;Department of Traditional Chinese and Western Medicine,Tianyou Hospital Affiliated to Wuhan University of Science and Technology,Wuhan 430064,Hubei,China)

机构地区：[1]华中师范大学医院皮肤科/中西医结合科,湖北武汉430079 [2]湖北省中医院皮肤科,湖北武汉430060 [3]武汉市中西医结合医院皮肤科,湖北武汉430022 [4]武汉科技大学附属天佑医院中西医结合科,湖北武汉430064

出　　处：《江汉大学学报（自然科学版）》2022年第6期69-80,共12页Journal of Jianghan University：Natural Science Edition

基　　金：国家中医药管理局基金资助项目(2013-22);武汉市卫健委基金资助项目(WZ16B03)。

摘　　要：目的观察中药复方制剂敏脱乐配合火针疗法治疗慢性湿疹的临床疗效,并进一步探讨可能的作用机制。方法选取临床病例286例,随机双盲原则分为对照组和观察组。对照组给予西药常规抗过敏治疗,观察组给予中药方剂敏脱乐口服配合火针外治法。治疗4周之后评估疗效。进一步借助网络药理学和生物信息学理论,对两组患者治疗前后进行差异基因分析,选取INF-γ、IL-4及EOS、IgE作为疗效观察指标,探讨药物作用机制。结果临床观察中观察组有效率89.7%,对照组有效率77.2%,观察组治疗效果优于对照组(P<0.05)。评估湿疹面积和严重程度指数(EASI)和皮肤病生活质量指数(DLQI)评分变化,观察组评分下降较对照组明显(P<0.05)。实验研究中,观察组较对照组治疗后IL-4、EOS、IgE降低明显,INF-γ升高明显(P<0.05)。结论中药方剂敏脱乐配合火针疗法治疗慢性湿疹疗效确切,且能明显调节机体免疫机制,在湿疹治疗中起到积极作用,值得在临床中推广运用。Objective To observe the clinical efficacy of the traditional Chinese medicine compound Mintuole combined with fire acupuncture in the treatment of chronic eczema,and further explore the possible action mechanism.Methods A total of 286 clinical cases were selected and randomly divided into the control group and the observation group according to the double-blind principle.The control group was given conventional anti-allergic treatment,and the observation group was given Mintuole orally combined with fireneedling external therapy.Efficacy was assessed after 4 weeks of treatment.Further,based on network pharmacology and bioinformatics’theory,the differential genes of the two groups of patients were analyzed before and after treatment.INF-γ,IL-4,EOS,and IgE were selected as the efficacy observation indexes to explore the mechanism of drug action.Results In the clinical observation,the effective rate of the observation group was 89.7%and the effective rate of the control group was 77.2%.The therapeutic effect of the observation group was better than that of the control group(P<0.05).Eczema area and severity index(EASI)and dermatology life quality index(DLQI)scores were evaluated.The scores in the observation group decreased significantly compared with those in the control group(P<0.05).In the experimental study,compared with the control group,IL-4,EOS,and IgE in the observation group were significantly decreased,and INF-γwas significantly increased after treatment(P<0.05).Conclusion Mintuole combined with fire acupuncture therapy is effective in treating chronic eczema and can significantly regulate the body’s immune mechanism.

关 键 词：中药方剂 火针 慢性湿疹 疗效观察 作用机制 

分 类 号：R275.958.23[医药卫生—中西医结合]