人兽共患结核病疫苗研究进展  

Research progress on zoonotic tuberculosis vaccine

作　　者：张翩 陈强 朱志森 黄育浩[4] 李光洪 王晓虎 王刚 郭钊文 ZHANG Pian;CHEN Qiang;ZHU zhisen;HUANG Yuhao;LI Guanghong;WANG Xiaohu;WANG Gang;GUO Zhaowen(Institute of Animal Health,Guangdong Academy of Agricultural Sciences/Guangdong Key Laboratory of Livestock Disease Prevention/Guangdong Scientific Observation and Experiment Station of Veterinary Drugs and Diagnostic Techniques,Ministry of Agriculture and Rural Affairs,Guangzhou Guangdong 510640;Guiping animal quarantine station,Guigang City,Guangxi Zhuang Autonomous Region,Guigang Guangxi 537200;Dongguan Fenggang Town Agricultural Technology Service Center,Dongguan Guangdong 523000;Dongguan Center for Animal Disease Prevention and Control,Guangzhou Guangdong 523128;Guangdong Chuangsheng Agricultrual Development Co.,Ltd,Shaoguan Guangdong 512322;Qingyuan Shi Qingcheng qu Dong Wu Wei Sheng Fang Yi Zhong Xin,Qingyuan Guangdong 511500)

机构地区：[1]广东省农业科学院动物卫生研究所,广东省畜禽疫病防治研究重点实验室,农业农村部兽用药物与诊断技术广东科学观测研究站,广东广州510640 [2]广西壮族自治区贵港市桂平市动物检疫站,广西贵港537200 [3]东莞市凤岗镇农业技术服务中心,广东东莞523000 [4]东莞市动物疫病预防控制中心,广东东莞523128 [5]广东创盛农业发展有限公司,广东韶关512322 [6]清远市清城区动物卫生防疫中心,广东清远511500

出　　处：《广东畜牧兽医科技》2022年第6期34-39,共6页Guangdong Journal of Animal and Veterinary Science

基　　金：广东省自然科学基金项目(2020A1515011112);广东省科技项目(2021B1212050021);2022年自然资源事务专项资金-生态林业建设项目(4030132130299);广东省现代农业产业技术体系创新团队项目(2022KJ114)。

摘　　要：结核病是由结核杆菌感染引起的慢病传染病。由于没有有效的治疗药物,结核病仍在全球广泛流行,严重危害人们的健康。卡介苗(BCG)是目前唯一注册用于人类的结核病疫苗,虽然BCG可使儿童产生对结核病的抵抗力,但是不能有效预防成人和老年人结核病的发生。且随着耐药性菌株的增多以及HIV混合感染等问题的出现,迫切需要开发一种比卡介苗更安全、更有效的疫苗。本文就结核病疫苗的免疫机制、卡介苗的不足和候选结核疫苗的研究进展进行综述。Tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis. Due to the lack of effective treatment drugs,tuberculosis is still widespread in the world,seriously endangering people′s health. The BCG vaccine(Mycobacterium Bovis bacilli Calmette-Guérin,BCG)is the only TB vaccine currently registered for humans,although BCG can create resistance to TB in children,it cannot effectively prevent tuberculosis in adults and the elderly. And with the increase of drug-resistant strains and HIV mixed infection,it is urgent to develop a safer and more effective vaccine than BCG. This article provides a review of the immune mechanisms of tuberculosis,the shortcomings of BCG,and the research progress for candidate tuberculosis vaccines.

关 键 词：结核病 免疫 结核疫苗 卡介苗 全细胞候选疫苗 亚单位疫苗 

分 类 号：S855.2[农业科学—临床兽医学]