多杀性巴氏杆菌疫苗研究进展  

Research progress on pasteurella multocida vaccine

作　　者：赵梦坡 朱志森 黄育浩[4] 王晓虎 申丽萍 袁子国[2] 王刚 郭钊文 ZHAO Mengpo;ZHU Zhisen;HUANG Yuhao;WANG Xiaohu;SHEN Liping;YUAN Zigou;WANG Gang;GUO Zhaowen(Institute of Animal Health,Guangdong Academy of Agricultural Sciences/Guangdong Key Laboratory of Livestock Disease Prevention/Guangdong Scientific Observation and Experiment Station of Veterinary Drugs and Diagnostic Techniques,Ministry of Agriculture and Rural Affairs,Guangzhou Guangdong 510640;College of Veterinary Medicine,South China Agricultural University,Guangzhou Guangdong 510642;Dongguan Fenggang Town Agricultural Technology Service Center,Dongguan Guangdong 523000;Dongguan Center for Animal Disease Prevention and Control,Dongguan Guangdong 523128;Shaoguan Danxia Agricultrual Development Co.,Ltd,Shaoguan Guangdong 512335;Qingyuan Shi Qingcheng qu Dong Wu Wei Sheng Fang Yi Zhong Xin,Qingyuan Guangdong 511500)

机构地区：[1]广东省农业科学院动物卫生研究所,广东省畜禽疫病防治研究重点实验室,农业农村部兽用药物与诊断技术广东科学观测研究站,广东广州510640 [2]华南农业大学兽医学院,广东广州510642 [3]东莞市凤岗镇农业技术服务中心,广东东莞523000 [4]东莞市动物疫病预防控制中心,广东东莞523128 [5]韶关丹霞农业科技有限公司,广东韶关512335 [6]清远市清城区动物卫生防疫中心,广东清远511500

出　　处：《广东畜牧兽医科技》2022年第6期45-51,共7页Guangdong Journal of Animal and Veterinary Science

基　　金：广东省自然科学基金项目(2020A1515011112);广东省科技项目(2021B1212050021);2022年自然资源事务专项资金-生态林业建设项目;家禽重要疫病高效生物制剂的研制及转化项目(202101001);广东省现代农业产业技术体系创新团队项目(2022KJ114)。

摘　　要：多杀性巴氏杆菌相关疾病是由多杀性巴氏杆菌(Pasteurella multocida,Pm)引起一种广泛存在于全世界大部分地区的人兽共患病,该菌可感染牛、羊、猪、兔等多种家畜,引起出血性败血症和传染性肺炎,给养殖业造成了巨大的经济损失。目前,Pm疾病的防控手段主要是给家畜接种Pm减毒疫苗和灭活疫苗,但是由于Pm具有不同的血清型,Pm疫苗对动物起到的免疫保护效果不太理想。本文对Pm的分型、Pm的毒力因子特点及Pm基因工程疫苗研究过程中的新发现进行总结,以期为新型Pm疫苗研究以及免疫策略的制定提供借鉴。Pasteurella multocida-associated disease is a human-animal disease caused by Pasteurella multocida(Pm),which is widespread in most parts of the world. Infection with Pm in cattle,sheep,pigs,rabbits,and other livestock can cause hemorrhagic septicemia and infectious pneumonia,causing huge economic losses to the livestock and poultry farming industry. At present,the prevention and control of Pm disease is mainly through the vaccination of livestock with attenuated Pm vaccine and inactivated vaccine,but because Pm has different serotypes,the immune protection of Pm vaccine on animals is less than ideal. Therefore,this paper summarizes the typing of Pm,the characteristics of Pm virulence factors. and new findings in the research of Pm genetically engineered vaccines,to provide reference for the research of new Pm vaccines and the development of immunization strategies.

关 键 词：多杀性巴氏杆菌 血清学分型 毒力因子 疫苗 

分 类 号：S856.3[农业科学—临床兽医学]