血清VEGF、IGF-1水平与脑胶质瘤患者手术治疗预后的相关性  

Correlation Between Serum VEGF And IGF-1 Levels and Prognosis of Patients with Glioma After Surgical Treatment

作　　者：奚再兴[1] 何小姣[1] XI Zaixing;HE Xiaojiao(Department of Neurosurgery,Nanyang First People’s Hospital,Nanyang 473000,China)

机构地区：[1]南阳市第一人民医院神经外科,河南南阳473000

出　　处：《河南医学研究》2022年第23期4293-4296,共4页Henan Medical Research

摘　　要：目的观察血清血管内皮生长因子(VEGF)、胰岛素生长因子(IGF)-1水平在脑胶质瘤患者中的表达,并分析二者与脑胶质瘤手术治疗预后的关系,为探究脑胶质瘤潜在治疗靶点提供参考依据。方法选取南阳市第一人民医院神经外科2016年8月至2018年8月收治的96例脑胶质瘤患者作为研究对象,所有患者均在医院接受开颅胶质瘤切除术治疗,术后接受为期3 a随访,以随访期间患者生存情况评估治疗预后,分为预后不良(随访期间病死)和预后良好(随访结束仍存活),以随访期间病死视为随访终点事件。入院时即对患者进行相关检查,检查项目包括血清VEGF、IGF-1、癌胚抗原(CEA)、糖类抗原(CA)125、CA153,构建Cox回归分析模型,分析各指标与脑胶质瘤手术治疗预后的关系,绘制受试者工作特征(ROC)曲线,检验血清VEGF、IGF-1水平对脑胶质瘤手术治疗预后不良的预测价值。结果纳入的96例脑胶质瘤患者,术后随访期间预后不良占46.88%,预后良好占53.13%,两组患者一般资料相比较,差异无统计学意义(P>0.05)。预后不良组血清VEGF、IGF-1、CEA、CA153、CA125水平均高于预后良好组(P<0.05)。经Cox生存回归分析结果显示,血清VEGF、IGF-1、CA125过表达与脑胶质瘤患者手术治疗预后不良有关(P<0.05)。绘制ROC曲线显示,血清VEGF、IGF-1水平单独及联合预测脑胶质瘤患者手术治疗预后不良的曲线下面积(AUC)分别为0.829、0.826、0.895。结论血清VEGF、IGF-1过表达与脑胶质瘤患者手术治疗预后不良有关,术前检验血清VEGF、IGF-1水平可预测脑胶质瘤患者预后不良风险。Objective To observe the expression of serum vascular endothelial growth factor(VEGF)and insulin growth factor(IGF)-1 in patients with glioma,and to analyze the relationship between them and the prognosis of surgical treatment of glioma,so as to provide reference for exploring the potential therapeutic targets of glioma.Methods A total of 96 patients with glioma treated in Department of Neurosurgery of Nanyang First People’s Hospital from August 2016 to August 2018 were selected as the research subjects.All patients underwent craniotomy for glioma in the hospital,and the patients were followed up for 3 years after operation.The prognosis of treatment was evaluated by the survival of patients during the follow-up period,which was divided into poor prognosis(death during the follow-up period)and good prognosis(survival at the end of the follow-up period).Death during the follow-up period was regarded as the end point of follow-up.Upon admission,serum VEGF,IGF-1,carcinoembryonic antigen(CEA),carbohydrate antigen(CA)125,CA153 of the patients were examined.The Cox regression analysis model was constructed to analyze the relationship between each index and the prognosis of glioma surgery.The receiver operating characteristic(ROC)curve of the subjects was drawn to test the predictive value of serum VEGF and IGF-1 levels on the poor prognosis of glioma surgery.Results Among the included 96 patients with glioma,46.88%had poor prognosis and 53.13%had good prognosis,there was no statistical significant difference in the general data between the two groups(P>0.05).The levels of serum VEGF,IGF-1,CEA,CA153 and CA125 in the poor prognosis group were higher than those in the good prognosis group(P<0.05).The results of Cox survival regression analysis showed that the overexpression of serum VEGF,IGF-1 and CA125 were related to the poor prognosis of glioma patients after surgical treatment(P<0.05).The ROC curve showed that the areas under the curve(AUC)of serum VEGF and IGF-1 levels alone and in combination to predict the poor p

关 键 词：脑胶质瘤 开颅胶质瘤切除术 血管内皮生长因子 胰岛素生长因子-1 

分 类 号：R651.1[医药卫生—外科学]