基于脑-肠轴理论探讨小儿厌食症的发病机制  

Discussion on the Pathogenesis of Anorexia in Children Based on Brain-gut Axis Theory

作　　者：霍曼 杨志华[2] 赵志英 崔润芝 王宁[1] HUO Man;YANG Zhihua;ZHAO Zhiying;CUI Runzhi;WANG Ning(Grade 2020 Graduate,Gansu University of Traditional Chinese Medicine,Gansu Province,Lanzhou 730030,China;Department of Pediatrics,Gansu Hospital of Traditional Chinese Medicine,Gansu Province,Lanzhou 730050,China)

机构地区：[1]甘肃中医药大学,甘肃兰州730000 [2]甘肃省中医院儿内科,甘肃兰州730050

出　　处：《光明中医》2022年第19期3501-3504,共4页GUANGMING JOURNAL OF CHINESE MEDICINE

基　　金：甘肃省自然科学基金(No.20JR5RA160)。

摘　　要：近年来小儿厌食症对儿童生长发育的影响越来越严重。国内外学者研究发现,摄食行为与“脑肠肽-食欲中枢”系统关系密切,认为小儿厌食症产生的病因与脑肠肽分泌异常,脑-肠轴功能紊乱,进而导致胃肠动力不足有关。随着摄食行为在分子信号通路方面取得大量进展,越来越多的学者意识到脑肠肽对食欲调节的重要性。此文基于脑-肠轴理论从整体上探讨脑肠肽分泌异常与胃肠运动功能紊乱在小儿厌食症中的作用机制。In recent years,the influence of infantile anorexia on children’s growth and development has become more and more serious.Scholars at home and abroad have found that the control of appetite is closely related to the system of“brain-gut peptide appetite center”,and it is believed that the deficiency of gastrointestinal motility and abnormal secretion of brain-gut peptide may be the pathological results of anorexia in children.Much progress has been made in molecular signaling pathways along with feeding behavior.More and more scholars have realized the importance of brain-gut peptides in appetite regulation.Based on the brain-gut axis theory,this study explored the mechanism of gastrointestinal motor dysfunction and brain-gut peptide abnormality in children with anorexia.

关 键 词：脑-肠轴 脑肠肽 胆囊收缩素 小儿厌食症 发病机制 综述 

分 类 号：R272[医药卫生—中医儿科学]