屈螺酮炔雌醇片与去氧孕烯炔雌醇片治疗青春期无排卵性异常子宫出血合并中重度贫血的效果分析  

Efficacy analysis of drospirenone and ethinylestradiol tablets and desogestrel and ethinylestradiol tablets in the treatment of anovulatory abnormal uterine bleeding complicated with moderate to severe anemia in adolescents

作　　者：伍世端 梁惠虹 梁燕梅 张旗炘 伍少仪 黄秀妮 WU Shi-duan;LIANG Hui-hong;LIANG Yan-mei(Gaoyao District People's Hospital,Zhaoqing 526000,China)

机构地区：[1]肇庆市高要区人民医院,526000

出　　处：《中国实用医药》2022年第25期36-39,共4页China Practical Medicine

摘　　要：目的 探讨屈螺酮炔雌醇片与去氧孕烯炔雌醇片治疗青春期无排卵性异常子宫出血合并中重度贫血的临床效果。方法 23例青春期无排卵性异常子宫出血合并中重度贫血患者,以随机分组法分为A组(11例)和B组(12例)。A组患者给予屈螺酮炔雌醇片治疗, B组患者给予去氧孕烯炔雌醇片治疗。对比两组患者的治疗效果、出血控制时间、完全止血时间、1年内复发率及治疗前后子宫内膜厚度、血生化指标[血清白蛋白(ALB)、血红蛋白(Hb)]。结果 A组患者治疗总有效率90.91%与B组的83.33%对比,差异无统计学意义(P>0.05)。A组患者出血控制时间(19.69±2.86)h及完全止血时间(37.86±4.43)h均短于B组的(26.36±4.76)、(47.28±5.42)h,差异具有统计学意义(P<0.05);A组患者1年内复发率9.09%与B组的16.67%对比,差异无统计学意义(P>0.05)。治疗前,两组患者子宫内膜厚度及ALB、Hb水平对比,差异无统计学意义(P>0.05);治疗后, A组患者子宫内膜厚度(7.53±3.75)mm及ALB(39.27±3.84)g/L、Hb(75.60±12.18)g/L均优于治疗前的(17.87±3.85)mm、(12.28±1.36)g/L、(75.60±12.18)g/L, B组患者子宫内膜厚度(9.57±2.14)mm及ALB(37.02±3.15)g/L、Hb(122.40±9.31)g/L均优于治疗前的(16.92±3.84)mm、(12.87±1.36)g/L、(75.70±12.09)g/L,差异具有统计学意义(P<0.05);两组患者治疗后子宫内膜厚度及ALB、Hb水平组间对比,差异无统计学意义(P>0.05)。结论 在青春期无排卵性异常子宫出血合并中重度贫血患者治疗中屈螺酮炔雌醇片和去氧孕烯炔雌醇片均具有快速止血的效果,对降低子宫内膜厚度、改善血生化指标有显著作用,而屈螺酮炔雌醇片的出血控制时间及完全止血时间更短,在临床使用时应充分考虑患者具体情况进行选择。Objective To discuss the clinical effect of drospirenone and ethinylestradiol tablets and desogestrel and ethinylestradiol tablets in the treatment of anovulatory abnormal uterine bleeding complicated with moderate to severe anemia in adolescents. Methods A total of 23 adolescents with anovulatory abnormal uterine bleeding and moderate to severe anemia were randomly divided into group A(11 cases) and group B(12 cases). Patients in group A were treated with drospirenone and ethinylestradiol tablets, and patients in group B were treated with desogestrel and ethinylestradiol tablets. Both group were compared in terms of therapeutic effect,bleeding control time, complete hemostasis time, recurrence rate within 1 year, endometrial thickness, blood biochemical indexes [serum albumin(ALB), hemoglobin(Hb)] before and after treatment. Results The total effective rate in group A was 90.91%, and the difference was not statistically significant compared with 83.33% in group B(P>0.05). The bleeding control time(19.69±2.86) h and the complete hemostasis time(37.86±4.43) h in group A were shorter than(26.36±4.76) and(47.28±5.42) h in group B, and the differences were all statistically significant(P<0.05). The recurrence rate of patients in group A was 9.09% within 1 year, and the difference was not statistically significant compared with 16.67% in group B(P>0.05). Before treatment, there was no statistically significant difference in endometrial thickness, ALB and Hb levels between the two groups(P>0.05). After treatment, the endometrial thickness, ALB, Hb in group A were(7.53±3.75) mm,(39.27±3.84) g/L,(75.60±12.18) g/L, which were better than(17.87±3.85) mm,(12.28±1.36) g/L,(75.60±12.18) g/L before treatment;the endometrial thickness, ALB, Hb in group B were(9.57±2.14) mm,(37.02±3.15) g/L,(122.40±9.31) g/L, which were better than(16.92±3.84) mm,(12.87±1.36) g/L, and(75.70±12.09) g/L before treatment;the differences were all statistically significant(P<0.05). There was no statistically significant difference in

关 键 词：青春期无排卵性异常子宫出血 中重度贫血 屈螺酮炔雌醇片 去氧孕烯炔雌醇片 

分 类 号：R556[医药卫生—血液循环系统疾病] R711.52[医药卫生—内科学]