氨氯地平阿托伐他汀钙片治疗高血压、冠心病合并颈动脉粥样硬化的临床效果观察  

Clinical effect of amlodipine besylate and atorvastatin calcium tablets in the treatment of hypertension,coronary heart disease complicated with carotid atherosclerosis

作　　者：张万强 刘冰 ZHANG Wan-qiang;LIU Bing(Liaoning Health Industry Group Fuxin General Hospital,Fuxin 123000,China)

机构地区：[1]辽宁省健康产业集团阜新矿总医院,123000

出　　处：《中国实用医药》2022年第25期125-127,共3页China Practical Medicine

摘　　要：目的 观察氨氯地平阿托伐他汀钙片治疗高血压、冠心病合并颈动脉粥样硬化患者的临床效果。方法 100例高血压、冠心病合并颈动脉粥样硬化患者,以随机数字表法分为对照组和观察组,各50例。对照组采取氨氯地平治疗,观察组采取氨氯地平阿托伐他汀钙片治疗。比较两组临床疗效,治疗前后的颈动脉内膜中层厚度(IMT)、颈动脉粥样硬化病变体积(PV)。结果 观察组治疗总有效率为94.00%,高于对照组的80.00%,差异有统计学意义(P<0.05)。治疗后,观察组颈动脉IMT(0.14±0.11)cm3、颈动脉粥样硬化PV(1.12±0.19)mm均小于对照组的(0.25±0.10)cm3、(1.28±0.22)mm,差异有统计学意义(P<0.05)。结论 氨氯地平阿托伐他汀钙片在高血压、冠心病合并颈动脉粥样硬化患者的临床治疗中,能够在提高患者临床疗效的同时,进一步改善其颈动脉粥样硬化斑块情况。Objective To observe the clinical effect of amlodipine besylate and atorvastatin calcium tablets in the treatment of hypertension, coronary heart disease complicated with carotid atherosclerosis. Methods A total of 100 patients with hypertension, coronary heart disease complicated with carotid atherosclerosis were divided into control group and observation group by random numerical table, with 50 cases in each group. The control group was treated with amlodipine, and the observation group was treated with amlodipine andamlodipine besylate and atorvastatin calcium tablets. The clinical efficacy, carotid intima-media thickness(IMT) and carotid atherosclerotic lesion volume(PV) before and after treatment were compared between the two groups. Results The total effective rate of the observation group was 94.00%, which was higher than 80.00% of the control group,and the difference was statistically significant(P<0.05). After treatment, the carotid IMT(0.14±0.11) cm3 and carotid atherosclerosis PV(1.12±0.19) mm in the observation group were smaller than(0.25±0.10) cm3 and(1.28±0.22) mm in the control group, and the differences were statistically significant(P<0.05). Conclusion In the clinical treatment of patients with hypertension, coronary heart disease and carotid atherosclerosis, amlodipine besylate and atorvastatin calcium tablets can not only improve the clinical efficacy of patients, but also further improve their carotid atherosclerotic plaques.

关 键 词：氨氯地平阿托伐他汀钙片 氨氯地平 高血压 冠心病 颈动脉粥样硬化 疗效 

分 类 号：R544.1[医药卫生—心血管疾病] R541.4[医药卫生—内科学] R543.4[医药卫生—临床医学]