腹腔镜下子宫腺肌病病灶切除术联合GnRH-a治疗子宫腺肌病的临床疗效和安全性评价  

Clinical efficacy and safety of laparoscopic adenomyomectomy combined with Gn RH-a in the treatment of adenomyosis

作　　者：石佳 SHI Jia(Shenyang Anlian Maternal and Infant Hospital Co.,Ltd.,Shenyang 110044,China)

机构地区：[1]沈阳安联妇婴医院有限公司,110044

出　　处：《中国实用医药》2022年第25期150-152,共3页China Practical Medicine

摘　　要：目的 评估腹腔镜下子宫腺肌病病灶切除术联合促性腺激素释放激素激动剂(GnRH-a)治疗子宫腺肌病的临床疗效及安全性。方法 198例子宫腺肌病患者为研究对象,依据随机数字表法分为A组和B组,每组99例。A组采用腹腔镜下子宫腺肌病病灶切除术联合促性腺激素释放激素激动剂治疗, B组采用腹腔镜下子宫腺肌病病灶切除术治疗。对比两组子宫体积、血红蛋白水平、月经周期、月经量、术后痛经程度及并发症发生情况。结果 A组子宫体积(133.55±6.55)cm3小于B组的(257.50±7.58)cm3,血红蛋白(116.62±6.90)g/L高于B组的(90.50±5.82)g/L,月经周期(29.55±3.03)d长于B组的(27.82±4.36)d,月经量(68.25±4.13)ml少于B组的(106.62±6.00)ml,差异有统计学意义(P<0.05);A组术后痛经程度低于B组,差异有统计学意义(P<0.05);A组并发症发生率为3.03%,低于B组的15.15%,差异有统计学意义(P<0.05)。结论 腹腔镜下子宫腺肌病病灶切除术联合促性腺激素释放激素激动剂治疗子宫腺肌病的临床疗效显著,有助于恢复临床各项指标,术后痛经程度、并发症发生率低,有效促进患者康复,值得临床推广应用。Objective To evaluate the clinical efficacy and safety of laparoscopic adenomyomectomy combined with gonadotropin-releasing hormone agonists(GnRH-a) in the treatment of adenomyosis. Methods A total of 198 patients with adenomyosis were selected as the research subjects, and they were divided into group A and group B according to the random numerical table, with 99 cases in each group. Group A was treated with laparoscopic adenomyomectomy combined with gonadotropin-releasing hormone agonist, and group B was treated with laparoscopic adenomyomectomy. The uterine volume, hemoglobin level, menstrual cycle, menstrual volume,degreee of postoperative dysmenorrhea, and occurrence of complications were compared between the two groups.Results In group A, the uterine volume was(133.55±6.55) cm3, which was smaller than(257.50±7.58) cm3in group B;the hemoglobin(116.62±6.90) g/L was higher than(90.50±5.82) g/L in group B;the menstrual cycle(29.55±3.03) d was longer than(27.82±4.36) d in group B;the menstrual volume(68.25±4.13) ml was less than(106.62±6.00) ml in group B;the differences were all statistically significant(P<0.05). The degree of postoperative dysmenorrhea in group A was lower than that in group B, and the difference was statistically significant(P<0.05). The incidence of complications in group A was 3.03%, which was lower than 15.15% in group B, and the difference was statistically significant(P<0.05). Conclusion Laparoscopic adenomyomectomy combined with gonadotropin-releasing hormone agonists has significant clinical efficacy in the treatment of adenomyosis, which is helpful to the recovery of clinical indicators and effectively promote the recovery of patients,with low degree of postoperative dysmenorrhea and incidence of complications. It is worthy of clinical promotion and application.

关 键 词：腹腔镜下子宫腺肌病病灶切除术 促性腺激素释放激素激动剂 子宫腺肌病 并发症 

分 类 号：R711.74[医药卫生—妇产科学]