急性痛风性关节炎住院患者的治疗现状调查  

Investigation on Treatment Status of Inpatients With Acute Gouty Arthritis

作　　者：柯金珍[1] 王昆[1] 魏吟秋[1] 陈秋林 谢黎崖[2] KE Jinzhen;WANG Kun;WEI Yinqiu;CHEN Qiulin;XIE Liya(Department of Pharmacy,the First Affiliated Hospital of Xiamen University,Xiamen Fujian 361003,China;Department of Research,the First Affiliated Hospital of Xiamen University,Xiamen Fujian 361003,China)

机构地区：[1]厦门大学附属第一医院药剂科,福建厦门361003 [2]厦门大学附属第一医院科研部,福建厦门361003

出　　处：《中国卫生标准管理》2022年第21期121-126,共6页China Health Standard Management

摘　　要：目的了解急性痛风性关节炎(acute gouty arthritis,AGA)住院患者的治疗现状,为AGA患者的合理治疗提供依据。方法调阅2018年1月—2020年12月厦门大学附属第一医院风湿免疫科151例AGA住院患者的首次病历,收集相关资料,包括:患者性别、年龄、疗程、病程、用药情况、疼痛数字评分、血尿酸值、治疗效果和合并疾病。结果(1)一般资料:男性(96.03%),女性(3.97%),平均年龄(52.57±14.06)岁,疗程(9.89±5.10)d,病程(9.61±7.32)年。(2)抗炎镇痛药频率:单一用药与联合用药例数相当,单一用药者例数略高于联合用药例数。用药出现的频率,非甾体类药物78例(51.65%),秋水仙碱66例(43.71%),糖皮质激素83例(54.97%);降尿酸治疗用药频率,联合用药者明显多于单一用药者,碱化尿液用药者104例(68.88%),位居第一,抑制尿酸生成用药者58例(38.41%),位居第二,促尿酸排泄药,苯溴马隆用药者43例(28.48%),位居第三。(3)入院后与出院前患者的疼痛数字评价(numerical rating scale,NRS)评分分别为(4.13±1.18)分和(1.15±0.82)分,差异有统计学意义(P<0.01);疼痛缓解率为98.01%。(4)入院后与出院前患者的UA值分别为(535.66±118.45)μmol/L和(417.86±104.71)μmol/L,差异有统计学意义(P<0.01),排除出院前检测血尿酸值高于入院后检测值者27例(17.88%)。(5)临床疗效,显效61例(40.40%),有效63例(41.72%),无效27例(17.88%),总有效率124例(82.12%)。(6)AGA合并症频数,最高是高血压49例(32.45%),其次是高血脂29例(19.20%),第三是糖尿病13例(8.61%)。AGA合并症者,合理用药率为92.47%。结论AGA住院患者的疼痛缓解率和降尿酸治疗有效率均较高,但是临床应该参考指南推荐,合理选择治疗用药。Objective To investigate the status quo of treatment of acute gouty arthritis(AGA)inpatients,and to provide evidence for rational treatment of AGA patients.Methods The first medical records of 151 AGA inpatients in the department of rheumatology and immunology of the First Affiliated Hospital of Xiamen University from January 2018 to December 2020 were reviewed.Relevant data was collected,including gender,age,course of treatment,course of disease,medication,pain score,blood uric acid value,therapeutic effect and complicated diseases.Results(1)General date:male(96.03%),female(3.97%),mean age(52.57±14.06)years old,course of treatment(9.89±5.10)days,course of disease(9.61±7.32)years.(2)Frequency of anti-inflammatory and analgesic drugs:the number of cases of single drug use was similar to that of combined drug use,and the number of cases of single drug use was slightly higher than that of combined drug use.The frequency of drug use was 78 cases(51.65%)of nonsteroidal drugs,66 cases(43.71%)of colchicine and 83 cases(54.97%)of glucocorticoids.There were 104 cases(68.88%)of alkalizing urine drugs,ranking the first place;58 cases(38.41%)of inhibiting uric acid production,ranking the second place;43 cases(28.48%)of uric acid excreting drugs,phenylbromarone,ranking the third place.(3)Numerical rating scale(NRS)scores of patients after admission and before discharge were(4.13±1.18)points and(1.15±0.82)points,respectively,and the difference was statistically significant(P<0.01).The pain relief rate was 98.01%.(4)The UA values of the patients after admission and before discharge were(535.66±118.45)μmol/L and(417.86±104.71)μmol/L,respectively,and the difference was statistically significant(P<0.01).27 cases(17.88%)whose uric acid value was higher than that after admission were excluded.(5)Clinical efficacy:61 cases(40.40%)were effective,63 cases(41.72%)were effective,27 cases(17.88%)were ineffective,and 124 cases(82.12%)were total effective.(6)The highest incidence of AGA complications was hypertension(49 cases)(32.4

关 键 词：痛风性关节炎 住院患者 治疗现状 调查 规范治疗 合理用药 

分 类 号：R285[医药卫生—中药学]