非那雄胺辅助经尿道前列腺剥除术治疗对良性前列腺增生患者下尿路症状和血清炎症因子水平的影响  

Effects of finasteride assisted TUERP on lower urinary tract symptoms and levels of serum inflammatory factors in patients with benign prostatic hyperplasia

作　　者：汤尧[1] 傅崇德[1] 高辉[1] 谢圣陶 刘晓彤[1] 焦林[1] TANG Yao;FU Chongde;GAO Hui;XIE Shengtao;LIU Xiaotong;JIAO Lin(Department of Urology,Xi'an Aerospace General Hospital,Xi'an 710000,Shaanxi,China)

机构地区：[1]西安航天总医院泌尿外科,西安710000

出　　处：《中国性科学》2022年第11期25-29,共5页Chinese Journal of Human Sexuality

基　　金：西安航天总医院科研项目(2018KY005);陕西省自然科学基础研究计划(2019JM-487)。

摘　　要：目的探讨非那雄胺辅助经尿道前列腺剥除术(TUERP)治疗对良性前列腺增生(BPH)患者下尿路症状(LUTS)和血清炎症因子水平的影响。方法选取2020年1月至2022年1月西安航天总医院收治的98例BPH患者作为研究对象。通过随机数字表法将其分为联合组和对照组,各49例。对照组给予TUERP治疗,联合组在对照组基础上给予非那雄胺进行辅助性治疗。在治疗前及治疗2个月后,采用国际前列腺症状评分表(IPSS)对两组的临床效果进行评估;统计两组的前列腺体积(PV)、移行区容积(TZV)、最大尿流量(Qmax)及残余尿量(RV);采用酶联免疫吸附试验(ELISA)法测定两组血清肿瘤坏死因子-α(TNF-α)、白介素-17(IL-17)、白介素-6(IL-6)水平;统计两组术后并发症发生情况。结果治疗2个月后,联合组临床总有效率明显高于对照组,差异具有统计学意义(P<0.05);治疗2个月后,联合组IPSS评分、TZV、PV及RV均明显低于对照组,Qmax明显高于对照组,差异具有统计学意义(P<0.05);治疗2个月后,联合组TNF-α、IL-17、IL-6水平明显低于对照组,差异具有统计学意义(P<0.05);两组并发症发生率比较,差异无统计学意义(P>0.05)。结论非那雄胺辅助TUERP治疗BPH患者,可以有效提高临床效果,减轻LUTS程度,改善炎症因子水平,且不会增加并发症。Objective To explore the effects of finasteride assisted transurethral enucleation resection of the prostate(TUERP)on lower urinary tract symptoms(LUTS)and levels of serum inflammatory factors in patients with benign prostatic hyperplasia(BPH).Methods A total of 98 patients with BPH admitted to Xi'an Aerospace General Hospital were enrolled as the research objects between January 2020 and January 2022.According to random number table method,they were divided into combination group(finasteride assisted TUERP)and control group(TUERP),49 cases in each group.Before and after 2 months of treatment,clinical effects in two groups were evaluated by international prostate symptom scale(IPSS).The prostate volume(PV),transitional zone volume(TZV),maximum flow rate(Qmax)and residual volume(RV)in two groups were statistically analyzed.The levels of serum tumor necrosis factor-α(TNF-α),interleukin-17(IL-17)and interleukin-6(IL-6)in two groups were detected by enzyme-linked immunosorbent assay(ELISA).The postoperative complications in two groups were statistically analyzed.Results After 2 months of treatment,total clinical response rate of combination group was significantly higher than that of control group(P<0.05).After 2 months of treatment,IPSS score,TZV,PV and RV in combination group were significantly lower than those in control group,while Qmax was significantly higher than that in control group(P<0.05).After 2 months of treatment,levels of TNF-α,IL-17 and IL-6 in combination group were significantly lower than those in control group(P<0.05).The difference in the incidence of complications between the two groups was no statistically significant(P>0.05).Conclusions Finasteride assisted TUERP can effectively improve clinical curative effect on BPH patients,alleviate LUTS and improve levels of inflammatory factors,without increasing complications.

关 键 词：非那雄胺 良性前列腺增生 下尿路症状 炎症因子 经尿道前列腺剥除术 

分 类 号：R697[医药卫生—泌尿科学]