右美托咪定复合酒石酸布托啡诺静脉自控镇痛对足月阴道分娩产妇潜伏期镇痛的有效性  

Efficacy of analgesia with dexmedetomidine combined with butorphanol tartrate PCIA in the latent period of full-term vaginal delivery parturients

作　　者：王圣华 赵贺 刘海涛 田利川 WANG Shenghua;ZHAO He;LIU Haitao;TIAN Lichuan(Department of Anesthesiology,Cangzhou People's Hospital,Cangzhou 061000,Hebei,China)

机构地区：[1]沧州市人民医院麻醉科,河北沧州061000

出　　处：《中国性科学》2022年第11期64-67,共4页Chinese Journal of Human Sexuality

基　　金：河北省卫生健康委科研基金项目(20200297)。

摘　　要：目的探讨右美托咪定复合酒石酸布托啡诺静脉自控镇痛(PCIA)对足月阴道分娩产妇潜伏期镇痛的有效性。方法将2018年1月至2021年6月沧州市人民医院接收的228例足月阴道分娩产妇随机分为对照组和研究组,各114人。对照组在分娩潜伏期行酒石酸布托啡诺PCIA镇痛,研究组在分娩潜伏期行右美托咪定复合酒石酸布托啡诺PCIA镇痛。对比两组不同时刻产妇疼痛程度、自控镇痛泵(PCA)按压次数及第一、第二、第三产程时间和新生儿阿氏评分、产妇不良反应发生率。结果两组产妇视觉模拟量表(VAS)评分在镇痛前即刻、镇痛后15min、1h、6h及宫口开全时依次降低(P<0.05),研究组镇痛后15min、1h、6h及宫口开全时VAS评分均低于对照组(P<0.05);研究组PCA有效按压次数和不良反应发生率均低于对照组(P<0.05);两组第一、第二、第三产程时间和新生儿阿氏评分比较,差异无统计学意义(P>0.05)。结论足月阴道分娩产妇在潜伏期行右美托咪定复合酒石酸布托啡诺PCIA相较于单独酒石酸布托啡诺PCIA能更高效缓解产妇疼痛,且对分娩产程和新生儿体征无明显不良影响,不良反应发生率低。Objective To investigate the efficacy of patient controlled intravenous analgesia(PCIA)with dexmedetomidine combined with butorphanol tartrate in the latency analgesia of the full-term vaginal delivery parturients.Methods 228 full-term vaginal delivery parturients received by Cangzhou People's Hospital from January 2018 to June 2021 were randomly divided into control group and study group with 114 parturients in each group.The control group received PCIA analgesia with butorphanol tartrate during the latent period of delivery,while the study group received PCIA analgesia with dexmedetomidine combined with butorphanol tartrate during the latent period of delivery.The degree of maternal pain at different times,the times of pressing patient-controlled analgesia(PCA)pump,the time of the first,second and third stage of delivery process,the neonatal Appar scores and the incidence rate of adverse reactions of parturients between two groups were compared.Results The visual analogue scale(VAS)scores of parturients in the two groups decreased successively at immediately before analgesia,15 min,1 h,6 h after analgesia and the time of full opening of uterine orifice(P<0.05).The VAS scores at 15 min,1 h,6 h after analgesia and the time of full opening of uterine orifice in the study group were lower than those in the control group(P<0.05).The times of effective pressing PCA and the incidence rate of adverse reactions in the study group were less than those in the control group(P<0.05).There was no significant difference between the two groups in the time of the first,second and third stage of delivery process and neonatal Appar scores(P>0.05).Conclusions Compared to PCIA analgesia with butorphanol tartrate alone,dexmedetomidine combined with butorphanol tartrate PCIA analgesia applied in the latent period of full-term vaginal delivery parturients can more effectively relieve maternal pain,and has no significant adverse effect on the delivery process and neonatal signs,and the incidence rate of adverse reactions is lower.

关 键 词：右美托咪定 酒石酸布托啡诺 静脉自控镇痛 阴道分娩 潜伏期 

分 类 号：R714[医药卫生—妇产科学]