银离子泡沫敷料的亚慢性全身毒性研究  

Research on Silver ion Foam Dressing in Subchronic Systemic Toxicity Test

作　　者：黄燕倩 莫怡飞 向健[1] 张晓丽 卢玉沛 杨立峰[1] HUANG Yan-qian;MO Yi-fei;XIANG Jian;ZHANG Xiao-li;LU Yu-pei;YANG Li-feng(Guangdong Medical Devices Quality Surveillance and Inspection Institute,Guangdong Guangzhou 510080)

机构地区：[1]广东省医疗器械质量监督检验所,广东广州510080

出　　处：《中国医疗器械信息》2022年第21期32-35,79,共5页China Medical Device Information

基　　金：广东省药品监督管理局科技创新项目(项目名称:体外循环器械重点实验室项目研究,项目编号:2021ZDZ01)。

摘　　要：目的:比较不同浸提比例下银离子泡沫敷料亚慢性全身毒性试验结果的差异。方法:对两组SD大鼠分别给予不同浓度的银离子泡沫敷料浸提液,综合比较临床观察、体重变化、血液学、血液生化、大体尸检和组织病理学检查结果,观察两组动物的亚慢性全身毒性反应。结果:浸提比例为0.4g/mL的银离子泡沫敷料浸提液,会导致大鼠体重增长缓慢。结论:提高银离子泡沫敷料的浸提比例,可以观测到大鼠全身毒性反应。Objective:To compare the subchronic systemic toxicity test results of silver ion foam excipients at different concentrations.Methods:Two groups of SD rats were given different concentrations of silver ion foam dressing extract respectively.The clinical observation,weight change,hematology,blood biochemistry,gross autopsy and histopathology were compared comprehensively,and the subchronic systemic toxicity of the two groups of animals was observed.Results:0.4g/mL silver ion foam dressing extract can cause slow weight gain in rats.Conclusion:By increasing the extraction ratio of silver ion foam dressing,systemic toxicity could be observed in rats.

关 键 词：银离子敷料 亚慢性全身毒性 给药浓度 

分 类 号：R994.1[医药卫生—毒理学]