LncRNA在年龄相关性眼病中的调控作用研究进展  

Research progress on regulation of lncRNA in age-related ophthalmopathy

作　　者：成天禹(综述) 管怀进(审校)[2] Cheng Tianyu;Guan Huaijin(Department of Ophthalmology,Jiaotong University Affiliated Sixth People's Hospital,Shanghai 200233,China;Department of Ophthalmology,Affiliated Hospital of Nantong University,Nantong 226100,China)

机构地区：[1]上海交通大学附属第六人民医院眼科,上海200233 [2]南通大学附属医院眼科,南通226100

出　　处：《中华实验眼科杂志》2022年第10期992-995,共4页Chinese Journal Of Experimental Ophthalmology

基　　金：国家自然科学基金项目(81770906)。

摘　　要：长链非编码RNA(lncRNA)是一类长度大于200个核苷酸并且不具备编码蛋白质功能的转录本。LncRNA在人类各种疾病中发挥的调控作用越来越受到重视,成为新的研究热点。近年来研究发现,与健康个体相比,lncRNA在年龄相关性黄斑变性(AMD)和年龄相关性白内障(ARC)患者中表达异常。LncRNA ZNF503-AS1、BANCR、MEG3可通过各自的机制影响视网膜色素上皮细胞功能,从而导致AMD的发展;lncRNA MIAT、TUG1、H19可通过竞争性结合微小RNA发挥重要的调控机制,从而影响ARC的发生和发展。本文主要综述AMD和ARC相关lncRNA领域中的研究进展,揭示不同lncRNA在其中发挥的作用机制,为阐明疾病机制提供新的视角,并为其诊疗提供新的生物标志物选择。Long non-coding RNA(lncRNA)is a class of transcripts longer than 200 nucleotides,which do not have the function of coding proteins.Widely involved in the progress of various human diseases,lncRNA has become a new research hotspot and the regulatory role of it has been paid more and more attention.Studies in recent years found that lncRNA is abnormally expressed in age-related macular degeneration(AMD)and age-related cataract(ARC)compared with healthy individuals.LncRNA ZNF503-AS1,BANCR and MEG3 can play important roles in regulating function of retinal pigment epithelial cell,which can lead to the development of AMD.LncRNA MIAT,TUG1 and H19 can have important regulatory effects through competitive binding with microRNAs,thus affecting the occurrence and development of ARC.This article reviewed the research progress of lncRNA in the AMD and ARC related field,revealed the role of different lncRNAs in the diseases,provided a new perspective for elucidating the mechanism of the diseases and found a new biomarker for the diagnosis and treatment of the diseases.

关 键 词：长链非编码RNA 年龄相关性黄斑变性 年龄相关性白内障 

分 类 号：R77[医药卫生—眼科]