一测多评法测和兴白花油中5种成分含量的研究  

Determination of the Content of Five Components in Hexing Baihua Liniments by QAMS

作　　者：陈高翩 黄俊忠[1] 徐万帮[1] 方竑 CHEN Gaopian;HUANG Junzhong;XU Wanbang;FANG Hong(Chinese Patent Medicine Room/Chinese Herbal Medicine Room,Department of traditional Chinese medicine,Guangdong Institute for Drug Control,Guangdong Province,Guangzhou 510700,China)

机构地区：[1]广东省药品检验所中成药室/中药材(饮片)室,广东广州510700

出　　处：《中国中医药现代远程教育》2022年第23期134-137,共4页Chinese Medicine Modern Distance Education of China

基　　金：广东省科技计划项目【No.2018B02027008】。

摘　　要：目的建立同时测定和兴白花油中5种成分的一测多评法,验证一测多评法应用在和兴白花油质量分析中的可行性与准确性。方法采用气相色谱法,以薄荷脑成分为内参物,建立该成分与樟脑、水杨酸甲酯、桉油精及芳樟醇的相对校正因子,并计算这4种成分相对应的含量,同时用外标法测定和兴白花油中5种成分的含量,将实测值与计算所得值作比较,评价一测多评法应用在质量控制中的准确性、科学性与可行性。结果一测多评法测得的和兴白花油5种成分的含量值与外标实测值没有显著性差异相对标准偏差[(RSD)<3%]。结论以薄荷脑为内参物同步测定和兴白花油中其他4种成分含量的一测多评法方法准确可行,稳定性良好。Objective To build a quantitative analysis of QAMS for five components in Hexing Baihua liniments and to verify the feasibility and accuracy of the application of the method in the quality analysis of Hexing Baihua liniments.Methods Taking menthol as the indicator,the relative correction factor(RCF)was established and the contents of methyl,salicylate,camphor,linalool and eucalyptus oil was calculated.At the same time,the content of five components in the oil was determined by external standard method,and the measured value was compared with the calculated value to evaluate the accuracy,scientificity and feasibility of applying QAMS in quality control.Results The accuracy of the method evaluation results show that there is no significant difference between the value measured by QAMS and the measured value of the external standard[relative standard deviation(RSD)<3%].Conclusion It is practicable and accurate to control the quality of Hexing Baihua liniments by the simultaneous determination of menthol,methyl salicylate,camphor,linalooland eucalyptus oil.The content of active components in Hexing Baihua liniments is stable.

关 键 词：一测多评法 和兴白花油 相对校正因子 含量测定 

分 类 号：R284.1[医药卫生—中药学]