电压门控钠通道在慢性疼痛药物发现中的研究进展  

Research progress of voltage-gated sodium channels in drug discovery for chronic pain

作　　者：羊健 杨清云 孙水根 冯怡[1] 张继全[1] YANG Jian;YANG Qingyun;SUN Shuigen;FENG Yi;ZHANG Jiquan(Engineering Research Center of Modern Preparation Technology of TCM(Ministry of Education),Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学中药现代制剂技术教育部工程研究中心,上海201203

出　　处：《安徽医药》2023年第1期5-9,共5页Anhui Medical and Pharmaceutical Journal

基　　金：上海市科学技术委员会科研计划项目(14401901400)。

摘　　要：由于发病率高、药物效果有限或治疗药物受限等原因,慢性疼痛的治疗一直是世界范围内研究人员关注的难题。电压门控钠通道(VGSCs)阻滞剂有较为显著的镇痛作用,目前已知与慢性疼痛相关的钠通道亚型主要有Nav1.3、Nav1.7、Nav1.8、Nav1.9。2021年8—9月进行了该研究,全面概括了上述钠通道亚型与慢性疼痛的关系,归纳出潜在候选药物临床前研究方法,以及已被证实安全有效的选择性钠通道阻滞剂品种,为选择性钠通道阻滞剂的开发提供参考。The treatment of chronic pain has always been a difficult problem concerned by researchers worldwide due to the high in‐cidence,limited drug effects or therapeutic drugs.Voltage-gated sodium channel(VGSCs)blockers have a significant analgesic effect.Currently,the sodium channel subtypes related to chronic pain mainly include Nav1.3,Nav1.7,Nav1.8 and Nav1.9.The study was con‐ducted from August to September 2021.This review comprehensively summarizes the relationship between the sodium channel sub‐types and chronic pain,generalizes the preclinical research methods of potential drug candidates,and provides a reference for the de‐velopment of selective sodium channel blockers that have been proven safe and effective.

关 键 词：慢性疼痛 镇痛药 电压门控钠通道阻滞剂 NAV1.1电压门控钠通道 NAV1.3电压门控钠通道 NAV1.7电压门控钠通道 NAV1.8电压门控钠通道 NAV1.9电压门控钠通道 综述 

分 类 号：R402[医药卫生—临床医学]