miRNA对肾足细胞损伤的影响  

Effect of miRNA on renal podocyte injury

作　　者：苑佳奇 沈晓丹 张志凤 丁海麦[1] 张学明[1] YUAN Jiaqi;SHEN Xiaodan;ZHANG Zhifeng;DING Haimai;ZHANG Xueming(School of Basic Medicine and Forensic Medicine,Baotou Medical College,Baotou 014040,China)

机构地区：[1]包头医学院基础医学与法医学院,内蒙古包头014040

出　　处：《包头医学院学报》2022年第12期86-90,共5页Journal of Baotou Medical College

基　　金：内蒙古自治区自然科学基金项目(2020MS08007);内蒙古自治区科技创新引导奖励资金项目(2019)。

摘　　要：微RNA(microRNAs;miRNA,又译小分子RNA)是真核生物中广泛存在的一种长21-23个核苷酸的RNA分子,可调节其他基因的表达。其通过与目标mRNA进行特异结合,作为许多细胞过程的关键参与者,抑制转录后基因表达,在调控基因表达、细胞周期、生物体发育等方面起着重要作用。最近的研究表明,microRNA在肾脏正常生理功能和疾病中有重要作用,可能成为肾脏疾病中的预后标记物和(或)潜在治疗目标。Objective:microRNAs(miRNA,also translated into small RNAs)is a kind of RNA molecule with 21-23 nucleotides in length widely existing in eukaryotes,which can regulate the expression of other genes.As a key participant in many cellular processes,it inhibits post-transcriptional gene expression by specifically binding to the target mRNA,and plays an important role in regulating gene expression,cell cycle,and biological development.Recent studies have shown that microRNAs play an important role in normal renal physiological functions and diseases,and may become prognostic markers and/or potential therapeutic targets in renal diseases.

关 键 词：MICRORNA 肾足细胞 肾脏疾病 

分 类 号：R692[医药卫生—泌尿科学]