基于正念的补充替代疗法对妊娠期糖尿病孕妇血糖水平和炎性因子及脂肪因子的影响研究  

Effects of Complementary and Alternative Therapy of Mindfulness on Blood Sugar and Inflammatory Biomarkers and Adipokines in Pregnant Women with Gestational Diabetes Mellitus

作　　者：舒玲 龚波[1] 王婧 粟艳林[2] SHU Ling;GONG Bo;WANG Jing;SU Yanlin(Department of Otorhinolaryngology Head and Neck Surgery,Changsha Central Hospital/the Affiliated Changsha Central Hospital,University of South China,Changsha 410004,China;Department of Obstetrics and Gynecology,Changsha Central Hospital/the Affiliated Changsha Central Hospital,University of South China,Changsha 410004,China)

机构地区：[1]湖南省长沙市中心医院南华大学附属长沙中心医院耳鼻咽喉头颈外科,410004 [2]湖南省长沙市中心医院南华大学附属长沙中心医院妇产科,410004

出　　处：《中国全科医学》2023年第5期563-568,582,共7页Chinese General Practice

基　　金：湖南省卫生健康委科研计划课题项目(C20201237)。

摘　　要：背景妊娠期糖尿病(GDM)的发病率居高不下,且在全球普遍流行,在中国GDM发生率高达14.8%,妊娠期高血糖严重威胁母婴健康。目的探讨GDM孕妇采用基于正念的补充替代疗法的干预效果。方法2021年3—12月采用便利抽样法选取在长沙市中心医院门诊进行产前检查的64例GDM孕妇,采用随机数字表法分为试验组(n=31)和对照组(n=33)。对照组采取常规心理护理、饮食宣教、运动指导,试验组在常规心理护理基础上采用8周基于正念的补充替代疗法。收集患者基线资料,比较两组孕妇干预前后血糖水平及炎性因子、丝氨酸蛋白抑制剂(vaspin)水平,随访新生儿结局指标(出生体质量、随机血糖)。结果干预后试验组孕妇空腹血糖、餐后1 h血糖、餐后2 h血糖、白介素6、白介素8、肿瘤坏死因子α、vaspin水平低于对照组(P<0.05);干预后试验组空腹血糖、餐后1 h血糖、餐后2 h血糖、白介素6、白介素8、肿瘤坏死因子α、vaspin低于干预前(P<0.05);试验组GDM孕妇分娩时体质量、分娩时体质指数、妊娠期增重、分娩前糖化血红蛋白,新生儿出生体质量均低于对照组(P<0.05),试验组新生儿随机血糖高于对照组(P<0.05)。结论对GDM孕妇给予8周基于正念的补充替代疗法可降低其体质指数,有效控制血糖,降低炎性因子及脂肪因子水平,减少新生儿低血糖的发生。Background The incidence of gestational diabetes mellitus(GDM)remains high,and it is prevalent all over the world.The incidence of GDM in China is up to 14.8%.Intrauterine hyperglycemia during pregnancy is a severe threat to maternal and neonatal health.Objective The aim of this study was to evaluate the effect of mindfulness-based complementary and alternative therapy for GDM.Methods This study selected 64 pregnant women with GDM undergoing routine outpatient prenatal examination in Changsha Central Hospital by using convenience sampling from March to December 2021.These patients were randomly assigned into the intervention group(n=31)and the control group(n=33).The control group received routine psychologicalgcare,nutritional guidance and exercise guidance.The intervention group received 8 weeks of mindfulness-based complementary and alternative therapy on the basis of routine psychological care.This study collected the baseline characteristics and compared the blood sugar and inflammatory biomarkers and adipokines,followed-up neonatal outcomes(birth weight,random blood sugar).Results The fasting blood sugar level,1-hour blood sugar,2-hour blood sugar and the expression of interleukin-6,interleukin-8,tumor necrosis factor-αand vaspin were lower than those of the control group(P<0.05).After the intervention,the fasting blood sugar,1-hour blood sugar,2-hour blood sugar,and the expression of interleukin-6,interleukin-8,tumor necrosis factor-αand vaspin in the experiment group were lower than those before the intervention(P<0.05).The pre-delivey weight,pre-delivery BMI,gestational weight gain,pre-delivey HbA1c,birth weight of newborns of pregnant women with GDM in the intervention group were lower than those of the control group(P<0.05),and the random blood sugar of the intervention group was higher than that of the control group(P<0.05).Conclusion The 8 weeks of mindfulness-based complementary and alternative therapy reduced body mass index,effectively controlled blood sugar,reduced expression of inflammatory bi

关 键 词：糖尿病 妊娠 补充与替代医学 正念 炎症 脂肪因子 肿瘤坏死因子Α 

分 类 号：R714.256[医药卫生—妇产科学]