分娩前应用抗生素对GBS筛查阳性妊娠晚期孕妇围生期结局的影响  

Effect of antibiotic use before delivery on perinatal outcomes of GBS positive pregnant women in the third trimester

作　　者：唐玉 Tang Yu(Obstetrics department,Chongqing Rongchang maternal and child health hospital,ChongQing 402460,China)

机构地区：[1]重庆市荣昌区妇幼保健院产科,重庆402460

出　　处：《实用妇科内分泌电子杂志》2021年第32期31-33,共3页Electronic Journal of Practical Gynecological Endocrinology

摘　　要：目的 探讨分娩前应用抗生素对B族链球菌(GBS)筛查阳性妊娠晚期孕妇围生期结局的影响。方法 选取188例GBS筛查阳性妊娠晚期孕妇为研究对象,按照随机数字表法将其分为对照组与研究组,每组94例。对照组分娩前未给予抗生素治疗,研究组分娩前给予抗生素治疗。比较两组孕妇围生期结局、新生儿结局及脐血炎症水平。结果 研究组出现宫腔与产褥感染、产后出血、胎膜早破总发生率(8.51%)显著低于对照组(19.15%),差异有统计学意义(P<0.05);研究组高胆红素血症、感染总发生率(5.32%)低于对照组(14.89%),差异有统计学意义(P<0.05);两组Apgar评分比较差异无统计学意义(P>0.05);研究组C反应蛋白、白介素-6及降钙素原水平均低于对照组,差异有统计学意义(P<0.05)。结论 分娩前应用抗生素可显著改善GBS筛查阳性妊娠晚期孕妇围生期结局与新生儿结局,降低脐血炎症水平,且不影响新生儿机体状况。Objective To explore the effect of antibiotics before delivery on the perinatal outcome of pregnant women with positive group B streptococcus(GBS) screening in the third trimester. Methods 188 pregnant women in the third trimester positive for GBS screening were selected as the research objects and divided into control group and study group according to random number table method, with 94 cases in each group. The control group was not given antibiotics before delivery, while the study group was given antibiotics before delivery. The perinatal outcome, neonatal outcome and the level of umbilical cord blood inflammation were compared between the two groups. Results The total incidence of intrauterine and puerperal infection, postpartum hemorrhage and premature rupture of membranes in observation group(8.51%) was significantly lower than that in control group(19.15%), and the difference was statistically significant(P<0.05). The total incidence of hyperbilirubinemia and infection in observation group(5.32%)was lower than that in control group(14.89%), and the difference was statistically significant(P<0.05). There was no significant difference in Apgar score between the two groups(P>0.05). The average levels of C-reactive protein, interleukin-6 and calcitonin in observation group were lower than those in control group, and the difference was statistically significant(P<0.05). Conclusion Antibiotics before delivery can significantly improve the perinatal and neonatal outcomes of pregnant women with GBS screening positive in the third trimester, reduce the level of cord blood inflammation, and do not affect the physical condition of the newborn.

关 键 词：抗生素 B族链球菌 分娩前 妊娠晚期 

分 类 号：R714.25[医药卫生—妇产科学]