妊娠反应与孕期抑郁的关联研究  

Association between Morning Sickness and Depression in Pregnancy

作　　者：陈萌 游顶云 邢宸瑜 章锦曼[2] 李洪英 屈在卿[4] 朱蓓[4] CHEN Meng;YOU Dingyun;XING Chenyu;ZHANG Jinman;LI Hongying;QU Zaiqing;ZHU Bei(School of Public Health,Kunming Medical University,Kunming Yunnan 650500;Prenatal Diagnosis Center,The 1st People’s Hospital of Yunnan Province,Kunming Yunnan 650034;Dept.of Obstetrics,The 1st People’s Hospital of Qujing City,Qujing Yunnan 655099;Dept.of Obstetrics,The 1st Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650118,China)

机构地区：[1]昆明医科大学公共卫生学院,云南昆明650500 [2]云南省第一人民医院产前诊断中心,云南昆明650034 [3]曲靖市第一人民医院产科,云南曲靖655099 [4]昆明医科大学第一附属医院产科,云南昆明650118

出　　处：《昆明医科大学学报》2022年第12期30-35,共6页Journal of Kunming Medical University

基　　金：国家自然科学基金资助项目(81960592,82073569);云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目[2019FE001(-049),2019FE001(-303),202101AY07001-225];云南省基础研究专项-重点基金资助项目(202101AS070040);云南省基础研究专项-优秀青年基金资助项目(202001AW070021)。

摘　　要：目的 探讨妊娠反应相关情况与孕期抑郁之间的关联。方法 以在云南省3家医院进行产前检查的孕妇为研究对象,通过自制问卷收集孕妇信息,采用爱丁堡产后抑郁量表评定孕期抑郁。用卡方检验描述不同特征孕妇孕期抑郁发生情况,Logistic回归分析妊娠反应相关情况与孕期抑郁的关联。结果 纳入6 075名孕妇,孕期抑郁的检出率为35.64%。单因素分析结果显示,不同年龄、婚姻状况、居住地、职业状况、家庭年收入、文化程度、孕期、反应剧烈程度、反应持续时间和现阶段反应是否结束的孕妇孕期抑郁发生,差异均具有统计学意义(P <0.05)。多因素结果显示,妊娠反应剧烈程度剧烈、持续10周及以上和反应尚未结束的孕妇发生孕期抑郁的风险增高。结论 妊娠反应的剧烈程度和持续时间、目前反应是否结束与孕期抑郁存在关联。应加强妊娠相关知识的普及,减少孕期抑郁的发生,提高孕妇的心理健康水平。Objective To investigate the association between morning sickness and depression during pregnancy. Methods The pregnant women who underwent prenatal examination in 3 hospitals in Yunnan Province were selected. The information of pregnant women was collected by self-made questionnaire,and the Edinburgh Postpartum Depression Scale was used to assess depression in pregnancy. Chi-square test was used to describe the occurrence of pregnancy depression in pregnant women with different characteristics,and Logistic regression was used to analyze the correlation between morning sickness and prenatal depression. Results A total of 6 075pregnant women were included, and the detection rate of depression during pregnancy was 35.64%. Univariate analysis showed that there were statistically significant differences in pregnancy depression among pregnant women with different age,marital status,place of residence,occupational status,family annual income,educational level,gestational week,severity of morning sickness,duration of morning sickness,and whether the morning sickness is over(P < 0.05). Multivariate results showed that pregnant women with severe morning sickness,lasting10 weeks or more, and morning sickness that had not yet ended had an increased risk of depression during pregnancy. Conclusion The severity and duration of the morning sickness and whether it has ended are associated with depression during pregnancy. Health education on relevant infromation and knowledge should be strengthened to reduce the incidence of depression during pregnancy and improve the mental health of pregnant women.

关 键 词：孕妇 妊娠反应 孕期 抑郁 

分 类 号：R173[医药卫生—妇幼卫生保健]