cGAS-STING通路在调节肿瘤微环境中的研究进展  

Advances in the regulation of tumor microenvironment by cGAS-STING pathway

作　　者：王飘飘 董婧[1] 刘艳辉[1] 姚佳晨[1] 谢凡[1] 李文艳[1] WANG Piao-piao;DONG Jing;LIU Yan-hui;YAO Jia-chen;XIE Fan;LI Wen-yan(Department of Pharmacy,Gongli Hospital of Pudong New Area in Shanghai,Shanghai 200135)

机构地区：[1]上海市浦东新区公利医院药剂科,上海200135

出　　处：《中南药学》2022年第11期2470-2475,共6页Central South Pharmacy

基　　金：上海市浦东新区卫健委领先人才(No.PWRl2021-11)。

摘　　要：近年来,许多研究表明,激活cGAS-STING-IRF3信号通路可以在体内外产生较强的抗肿瘤作用。利用STING激动剂可以激活cGAS-STING-IRF3信号通路,诱导产生Ⅰ型干扰素,Ⅰ型干扰素可以促进树突状细胞活化,进而激活CD8^(+)T细胞发挥抗肿瘤作用。活化STING通路,可以调节肿瘤微环境中的各种免疫细胞,并且药物递送系统可以显著提升STING激动剂的抗肿瘤效果。此外,微生物以及机体自身的DNA损伤参与调节cGAS-STING信号通路影响肿瘤免疫的效果。本文将对cGAS-STING通路在肿瘤微环境中的作用进行综述。Recent research has shown that cGAS-STING-IRF3 signaling pathway can be activated to produce potent anti-tumor effect both in vitro and in vivo.The cGAS-STING-IRF3 signaling pathway can be activated by STING agonists,which results in the production of type I interferon.This type of interferon can increase the activation of dendritic cells,and in turn,stimulate CD8^(+)T lymphocytes to have anti-tumor effect.By turning on the STING pathway,different immune cells in the tumor microenvironment may be affected,and the drug delivery system can significantly boost the anti-tumor effect of STING agonists.Additionally,cGAS-STING pathway is modulated by microorganisms and DNA damage in order to modify anti-tumor immunotherapy.This paper discussed the role of cGAS-STING pathway in the tumor microenvironment.

关 键 词：cGAMP STING 肿瘤微环境 免疫系统 免疫疗法 

分 类 号：R96[医药卫生—药理学] R730.2[医药卫生—药学]