持续性房颤患者sST2和NT-pro BNP与左房内径关系的探讨  

Detection of sST-2 and NT-pro BNP levels in patients with persistent atrial fibrillation and their correlation with left atrium diameter

作　　者：钟海兰 ZHONG Hailan(Department of Cardiology,Jiangning Hospital of Nanjing,Affiliated Hospital,Nanjing Medical University,Nanjing,Jiangsu 211103,China)

机构地区：[1]南京医科大学附属南京市江宁医院心内科,江苏南京211103

出　　处：《医药前沿》2022年第27期26-28,32,共4页Journal of Frontiers of Medicine

摘　　要：目的:探讨非瓣膜病持续性房颤(pAF)患者血清可溶性基质裂解素2(sST2)、N-末端脑利钠肽前体(NT-pro BNP)的水平与左房内径(L A D)的相关性。方法:选取2020年12月—2022年4月南京市江宁医院心内科收治住院的105例非瓣膜病pAF患者,按LAD中位数大小,分为一组(35 mm<LAD<45 mm)53例、二组(45 mm≤LAD)52例。选同期住院的35例LAD正常(LAD≤35 mm)患者为对照组。采用酶联吸附免疫法测定血清中sST2、NT-pro BNP的水平,并分析其与LAD的关系。结果:sST2、NT-pro BNP水平在二组最高,在对照组最低,且二组>一组>对照组,差异有统计学意义(P<0.05),sST2、NT-pro BNP水平随着LAD增大而增高。sST2水平与LAD大小呈正相关(r=0.788,P<0.001);NT-pro BNP水平与LAD也呈正相关(r=0.739,P<0.001);sST2与NT-pro BNP水平亦呈正相关(r=0.893,P<0.001)。结论:sST2及NT-pro BNP与pAF患者左房结构发展密切相关,高水平sST2及NT-pro BNP可能预示着pAF患者预后及治疗效果较差。Objective To investigate the expression of serum souble ST-2(sST2),NT-pro BNP in non valvular persistent atrial fibrillation(pAF)patients with differrent left atrium diameter.Methods Totally 105 patients with pAF who were treated in the Department of Cardiology of the Jiangning Hospital of Nanjing from December 2020 to April 2022 were selected.Patients with pAF were divided into the first group(35 mm<LAD<45 mm,n=53),the second group(45 mm≤LAD,n=52).Totally 35(LAD≤35 mm)were selected as the control group during the same period of Cardiology.ELISA was performed to determine the serum sST-2 and NT-pro BNP level of the subjects.Spearman correlation analysis were conducted to investigate the correlation between sST2 and LAD.Results The serum sST-2 and NT-pro BNP level were the highest in the second group,Which were the lowest in the control group.the serumsST-2 and NT-pro BNP level of the second group was higher than the first group and control group,the difference in the 3 groups had statistical significance(P<0.05).The results showed that the concentration of sST2 was significantly positively correlated with the size of LAD(r=0.788,P<0.001).There was a significant positive correlation between NT-pro BNP and LAD in all experimental groups(r=0.739,P<0.001).Besides there was a significant positive correlation between sST2 and NT-proBNP concentrations in all experimental groups(r=0.893,P<0.001).Conclusions sST-2 and NT-pro BNP are closely related with the development of pAF.High levels of sST-2 and NT-pro BNP may indicate poor prognosis and treatment effects in patients with pAF.

关 键 词：持续性房颤 血清可溶性基质裂解素2 N-末端脑利钠肽前体 左房内径 

分 类 号：R54[医药卫生—心血管疾病]