自体微粒皮联合大张异种猪皮移植修复大面积烧伤创面的临床研究  

Clinical Study on Repair of Large Area Burn Wounds with Autologous Microskin Combined with Large-piece Xenograft of Pig Skin Transplantation

作　　者：王曌华 赵培东 卢文霄 张永 杨文元 裴敬仲 武延朋 WANG Zhaohua;ZHAO Peidong;LU Wenxiao;ZHANG Yong;YANG Wenyuan;PEI Jingzhong;WU Yanpeng(The First Department of Burns,the Second People’s Hospital of Xinxiang,Xinxiang 453000,Henan,China)

机构地区：[1]新乡市第二人民医院烧伤一科,河南新乡453000

出　　处：《中国美容医学》2022年第12期24-26,共3页Chinese Journal of Aesthetic Medicine

基　　金：河南省医学科技攻关计划联合共建项目(编号:LHGJ20200971)。

摘　　要：目的:探讨大面积烧伤患者采用自体微粒皮联合大张新鲜异种猪皮移植修复的临床效果。方法:选取2017年1月-2021年1月笔者医院收治的30例大面积烧伤患者作为研究对象。随机分为对照组(13例)和治疗组(17例),患者伤后3~7d,待患者生命体征平稳,治疗组采用自体微粒皮+大张异种猪皮移植修复,对照组采用自体微粒皮+脱细胞异体真皮修复。记录两组微粒皮扩展比、白蛋白应用时间、抗生素应用时间、植皮区感染面积百分比、微粒皮成活率及换药次数。结果:两组微粒皮扩展比、白蛋白及抗生素应用时间比较差异无统计学意义(P>0.05)。治疗组植皮区感染面积百分比少于对照组,微粒皮成活率及换药次数高于对照组,差异均有统计学意义(P<0.05)。结论:大张异种皮可有效提高微粒皮移植后的成活率,对微粒皮扩展比例没有明确的不良影响,是临床植皮时的一种不错选择。Objective To investigate the clinical effect of repairing large area burn wounds with autologous microskin and largepiece xenograft of pig skin transplantation.Methods 30 patients with large area burns admitted to our hospital from January 2017 to January 2021 were selected as the research objects.The were 13 patients in the control group and 17 patients in the treatment group.At 3-7 days after injury,when the vital signs of the patients were stable,the treatment group was repaired with autologous microskin+large-piece xenograft of pig skin transplantation,while the control group was repaired with autologous microskin+acellular allogeneic dermis.The expansion ratio of microparticle skin,the application time of albumin,the application time of antibiotic,the percentage of infected area in the skin graft area,the survival rate of microparticle skin and the number of dressing changes were recorded.Results There was no significant difference between the two groups in micro skin expansion ratio,albumin and antibiotic application time(P>0.05).The percentage of infected area in the skin grafting area in the treatment group was less than that in the control group,and the survival rate and dressing change times of microparticle skin in the treatment group were higher than those in the control group,the differences were statistically significant(P<0.05).Conclusion Large allogeneic skin can effectively improve the survival rate of microskin transplantation,there is no definite adverse effect on the expansion ratio of microskin,it is a good choice for clinical skin grafting.

关 键 词：大面积烧伤 自体微粒皮 移植修复 异种猪皮 脱细胞异体真皮 成活率 拓展比 

分 类 号：R644[医药卫生—外科学]