不同脉宽595 nm染料激光联合5-FU治疗增生性瘢痕的疗效以及对瘢痕血流灌注的影响  

Effect of 595 nm Dye Laser Different Pulse Width Laser Combined with 5-FU on Hypertrophic Scar and Its Influence on Blood Perfusion

作　　者：宫昕晨 陈明懿[2] GONG Xinchen;CHEN Mingyi(Department of Medical Equipment,Sichuan Provincial People's Hospital,University of Electronic Science and Technology of China,Chengdu 610072,Sichuan,China;Department of Dermatology,Sichuan Provincial People's Hospital,University of Electronic Science and Technology of China,Chengdu 610072,Sichuan,China)

机构地区：[1]四川省医学科学院·四川省人民医院医学装备部,四川成都610072 [2]四川省医学科学院·四川省人民医院皮肤科,四川成都610072

出　　处：《中国美容医学》2022年第12期87-90,共4页Chinese Journal of Aesthetic Medicine

摘　　要：目的:探讨不同脉宽激光联合5-氟尿嘧啶(5-Fluorouracil,5-FU)治疗增生性瘢痕的疗效及对瘢痕血流灌注的影响。方法:选取2020年8月-2021年12月于笔者医院行脉冲染料激光(Pulsed dye laser,PDL)联合5-FU治疗的86例增生性瘢痕患者为研究对象,根据患者就诊顺序分为观察组和对照组,每组43例。观察组和对照组PDL脉宽分别为1.5 ms和6 ms,观察比较两组患者治疗前后温哥华瘢痕量表评分(Vancouver scar scale,VSS)、视觉模拟评分(Visual analogue scale,VAS)和血流灌注情况,并比较两组患者临床疗效。结果:治疗前,两组患者各项指标比较,差异无统计学意义(P>0.05);治疗后,两组均较前显著改善,其中观察组血管分布评分和血流灌注显著低于对照组,差异有统计学意义(P<0.05),而色泽、柔软度、厚度和VAS评分比较,差异无统计学意义(P>0.05),两组患者临床疗效比较,差异无统计学意义(P>0.05)。结论:应用1.5 ms或6 ms脉宽PDL联合5-FU治疗增生性瘢痕疗效相当,其中1.5 ms脉宽PDL联合5-FU在消除微血管方面作用更强。Objective To explore the effect of 595 nm dye laser different pulse width laser combined with 5-FU on hypertrophic scar and its influence on blood perfusion. Methods 86 patients with hypertrophic scar who underwent PDL combined with 5-FU in our hospital from August 2020 to December 2021 were selected as the study subjects and divided into observers and control groups according to the order of presentation, 43 patients in each group. The PDL pulse width in the observation group and the control group was 1.5 ms and 6 ms, respectively. The Vancouver scar scale(VSS) score, visual analogue scale(VAS) and blood perfusion indexes were observed and compared between the two groups before and after treatment, and the clinical efficacy was compared between the two groups. Results There was no statistical difference in various indicators before treatment between the two groups(P>0.05), which were significantly improved after treatment, in which the vascularity score and blood perfusion in the observation group were significantly lower than those in the control group(P<0.05), while there was no significant difference in color, softness, thickness and VAS score(P>0.05), and there was also no significant difference in the clinical efficacy between the two groups(P>0.05). Conclusion The application of 1.5 ms or 6 ms pulse width PDL combined with 5-FU was equally effective in the treatment of hypertrophic scars, with 1.5 ms pulse width PDL combined with 5-FU having a stronger effect in eliminating microvessels.

关 键 词：不同脉宽 脉冲染料激光 5-氟尿嘧啶 增生性瘢痕 血流灌注 

分 类 号：R619.6[医药卫生—外科学]