经肺动脉置管溶栓治疗急性肺栓塞合并下肢深静脉血栓的临床效果  

Clinical effect of pulmonary artery catheter-directed thrombolysis in the treatment of acute pulmonary embolism with deep venous thrombosis of lower extremities

作　　者：陈欢 冯琦[1] CHEN Huan;FENG Qi(Baoji Hospital of Traditional Chinese Medicine,Baoji 721000,China)

机构地区：[1]宝鸡市中医医院,陕西宝鸡721000

出　　处：《临床医学研究与实践》2022年第36期99-101,共3页Clinical Research and Practice

摘　　要：目的探讨经肺动脉置管溶栓治疗急性肺栓塞合并下肢深静脉血栓的临床效果。方法选取2019年6月至2020年6月我院收治的77例急性肺栓塞合并下肢深静脉血栓患者作为研究对象,根据奇偶法将其分成试验组(39例)与参照组(38例)。试验组应用经肺动脉置管溶栓治疗,参照组应用经患肢静脉置管溶栓治疗。比较两组的体征指标及生化指标。结果治疗后,两组的收缩压、舒张压、心率均降低,血氧分压均升高,差异具有统计学意义(P<0.05);试验组的收缩压、舒张压低于参照组,心率高于参照组,差异具有统计学意义(P<0.05);两组的血氧分压比较,差异无统计学意义(P>0.05)。治疗后,两组的国际标准化比值、D-二聚体、心房利钠尿肽前体水平及肺动脉收缩压均降低,纤维蛋白原水平、血小板计数均升高,差异具有统计学意义(P<0.05);试验组的D-二聚体水平低于参照组,差异具有统计学意义(P<0.05);两组的国际标准化比值、纤维蛋白原水平、血小板计数、心房利钠尿肽前体水平、肺动脉收缩压比较,差异无统计学意义(P>0.05)。结论经肺动脉置管溶栓治疗急性肺栓塞合并下肢深静脉血栓的临床效果显著,患者的体征及生化指标均有所改善。Objective To explore the clinical effect of pulmonary artery catheter-directed thrombolysis in the treatment of acute pulmonary embolism with deep venous thrombosis of lower extremities.Methods A total of 77 patients with acute pulmonary embolism with deep venous thrombosis of lower extremities admitted in our hospital from June 2019 to June 2020 were selected as the research objects,and the patients were divided into experimental group(39 cases)and reference group(38 cases)according to parity method.The experimental group was treated with pulmonary artery catheter-directed thrombolysis,and the reference group was treated with thrombolysis via venous catheterization of affected limb.The signs and biochemical indexes of the two groups were compared.Results After treatment,the systolic pressure,diastolic pressure and heart rate of the two groups decreased,the partial pressure of oxygen increased,and the differences were statistically significant(P<0.05);the systolic pressure and diastolic pressure in the experimental group were lower than those in the reference group,and the heart rate was higher than that in the reference group,and the differences were statistically significant(P<0.05);there was no significant difference in the partial pressure of oxygen between the two groups(P>0.05).After treatment,the international normalised ratios,D-dimer,atrial natriuretic peptide precursor levels and pulmonary artery systolic pressure decreased,the fibrinogen level and platelet count increased,and the differences were statistically significant(P<0.05);the D-dimer level in the experimental group was lower than that in the reference group,and the difference was statistically significant(P<0.05);there were no significant differences in the international normalised ratios,fibrinogen level,platelet count,atrial natriuretic peptide precursor level and pulmonary artery systolic pressure between the two groups(P>0.05).Conclusion Pulmonary artery catheter-directed thrombolysis on acute pulmonary embolism with deep venous thrombosis

关 键 词：急性肺栓塞 下肢深静脉血栓 经肺动脉置管溶栓 

分 类 号：R563.5[医药卫生—呼吸系统] R543.6[医药卫生—内科学]