急性重度药物中毒患者采用急诊床边血液灌流治疗的临床疗效分析  

Clinical Efficacy Analysis of Emergency Bedside Hemoperfusion in Patients with Acute Severe Drug Poisoning

作　　者：孟和勿力吉 Menghewuliji(Emergency Department,Inner Mongolia Hulunbuir City People's Hospital,Hulunbuir,Inner Mongolia Autonomous Region,021008 China)

机构地区：[1]内蒙古呼伦贝尔市人民医院急诊科,内蒙古呼伦贝尔021008

出　　处：《世界复合医学》2022年第10期131-134,163,共5页World Journal of Complex Medicine

摘　　要：目的分析急性重度药物中毒患者采用急诊床边血液灌流治疗的临床疗效。方法选取内蒙古呼伦贝尔市人民医院2021年1—10月收治的20例急性重度药物中毒患者作为研究对象,按随机数表法分为对照组和观察组,各10例。对照组患者给予解毒治疗+急诊内科综合治疗,观察组患者给予急诊床边血液灌流治疗,比较两组患者临床疗效、昏迷时间和住院天数、治疗后的血清酶和肝肾功能指标及并发症情况和治疗前后血常规及电解质指标。结果观察组抢救成功率90%高于对照组的40%,差异有统计学意义(P<0.05);观察组昏迷时间、住院天数明显比对照组短,差异有统计学意义(t=6.380、2.580,P<0.05),观察组治疗后肝肾功能指标、血清酶指标、ChE水平较对照组更优,差异有统计学意义(P<0.05)。两组所有患者治疗后未出现并发症情况。结论对急性重度药物中毒患者给予床边血液灌流治疗,可提高患者抢救成功率、减少病死率,治疗后未出现并发症情况,治疗安全性高,相比于常规内科治疗,床边血液灌流治疗效果显著。Objective To investigate and analyze the clinical efficacy of emergency bedside hemoperfusion in patients with acute severe drug poisoning.Methods 20 patients with acute severe drug poisoning admitted to Inner Mongolia Hulunbuir City People's Hospital from January to October 2021 were selected as the research subjects.According to the random number table method,they were divided into control group and observation group,with 10 cases in each group.The control group was given detoxification treatment+emergency medical comprehensive treatment,and the observation group was given emergency bedside hemoperfusion therapy.The clinical efficacy,coma time and hospitalization days,serum enzymes,liver and kidney function indexes,and complications after treatment,and the blood routine and electrolyte indexes before and after treatment were compared between the two groups.Results The rescue success rate of the observation group was 90% higher than that of the control group(40%),the difference was statistically significant(P<0.05);the coma time and hospitalization days of the observation group were significantly shorter than those of the control group,the difference was statistically significant(t=6.380,2.580,P<0.05);after treatment,liver and kidney function indexes,serum enzyme indexes,ChE level of the observation group were more significant than that of the control group,the difference was statistically significant(P<0.05).No complications occurred in all patients in the two groups after treatment.Conclusion Bedside hemoperfusion therapy for patients with acute severe drug poisoning can improve the rescue success rate and reduce the mortality rate.There are no complications after treatment,and the treatment is safe.Compared with conventional medical treatment,the effect of bedside hemoperfusion treatment is significant.

关 键 词：急性重度药物中毒 血液灌流 疗效 并发症 血清酶 肝肾功能 

分 类 号：R595.4[医药卫生—内科学]