2,3-萘二甲酸酐的合成研究  

Synthesis research of 2,3-naphthalenedicarboxylic anhydride

作　　者：张成新 王玉华 王晓环 王俊青 ZHANG Cheng-xin;WANG Yu-hua;WANG Xiao-huan;WANG Jun-qing(Shandong Key Laboratory of Marine Fine Chemicals,Shandong Ocean Chemical Industry Scientific Research Institute,Weifang 262737,China;Basic Teaching Department,Shandong Vocational Animal Science and Veterinary College,Weifang 261061,China)

机构地区：[1]山东省海洋精细化工重点实验室,山东省海洋化工科学研究院,山东潍坊262737 [2]山东畜牧兽医职业学院基础教学部,山东潍坊261061

出　　处：《化学研究与应用》2022年第12期3000-3003,共4页Chemical Research and Application

摘　　要：2,3-萘二甲酸酐是合成医药、染料、感光材料的重要中间体。本文以马来酸二乙酯、邻苯二甲醛为原料,经Wittig反应、Knoevenagel缩合反应、酯水解反应、脱水缩合反应得到目标化合物,产物结构经(1)^H NMR和GC-MS确证。本文采用的合成方法简单、产品收率及纯度高,总收率达80.6%,GC纯度达到99.5%以上,适合工业化生产。2,3-Naphthalenedicarboxylic anhydride is an important intermediate in synthesis of medicine,dyes and photosensitive materials.In this paper,the target compound was obtained by the reaction of Wittig reaction,Knoevenagel condensation,ester hydrolysis and dehydration condensation,using o-phthalaldehyde and diethyl maleate as starting material.The structure of product was confirmed by(1)^H NMR and GC-MS.The synthesis route adopted in this paper had the advantages of simple synthesis method,high product yield and purity.The total yield was up to 80.5%,GC purity was over 99.5%.This process was suitable for large-scale industrial production.

关 键 词：2 3-萘二甲酸酐 WITTIG反应 KNOEVENAGEL缩合 合成方法 

分 类 号：O625.29[理学—有机化学]