Biomechanics and mechanobiology of the bone matrix  

作　　者：Chunyang Ma Tianming Du Xufeng Niu Yubo Fan 

机构地区：[1]Key Laboratory of Biomechanics and Mechanobiology(Beihang University),Ministry of Education,Beijing Advanced Innovation Center for Biomedical Engineering,School of Biological Science and Medical Engineering,Beihang University,Beijing 100083,China [2]Department of Biomedical Engineering,Faculty of Environment and Life,Beijing University of Technology,Beijing 100124,China [3]Research Institute of Beihang University in Shenzhen,Shenzhen 518057,China [4]School of Engineering Medicine,Beihang University,Beijing 100083,China

出　　处：《Bone Research》2022年第4期644-660,共17页骨研究（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.11872097,11827803 and U20A20390);the National Key R&D Program of China(No.2020YFC0122204);the 111 Project(No.B13003).

摘　　要：The bone matrix plays an indispensable role in the human body,and its unique biomechanical and mechanobiological properties have received much attention.The bone matrix has unique mechanical anisotropy and exhibits both strong toughness and high strength.These mechanical properties are closely associated with human life activities and correspond to the function of bone in the human body.None of the mechanical properties exhibited by the bone matrix is independent of its composition and structure.Studies on the biomechanics of the bone matrix can provide a reference for the preparation of more applicable bone substitute implants,bone biomimetic materials and scaffolds for bone tissue repair in humans,as well as for biomimetic applications in other fields.In providing mechanical support to the human body,bone is constantly exposed to mechanical stimuli.Through the study of the mechanobiology of the bone matrix,the response mechanism of the bone matrix to its surrounding mechanical environment can be elucidated and used for the health maintenance of bone tissue and defect regeneration.This paper summarizes the biomechanical properties of the bone matrix and their biological significance,discusses the compositional and structural basis by which the bone matrix is capable of exhibiting these mechanical properties,and studies the effects of mechanical stimuli,especially fluid shear stress,on the components of the bone matrix,cells and their interactions.The problems that occur with regard to the biomechanics and mechanobiology of the bone matrix and the corresponding challenges that may need to be faced in the future are also described.

关 键 词：STRUCTURE TOUGHNESS MATRIX 

分 类 号：R318.01[医药卫生—生物医学工程]