高通量透析联合Supra-HFR血滤吸附对维持性血液透析患者甲状旁腺素和β2-微球蛋白的清除效果  

Effect of high-flux hemodialysis and Supra-HFR on parathyroid hormone and β2-microglobulin removal in maintenance hemodialysis patients

作　　者：冯艳翠[1] 余柏林 张海红[1] FENG Yan-cui;YU Bai-lin;ZHANG Hai-hong(Department of Nephrology,Kaiping Central Hospital,Kaiping 529300,China)

机构地区：[1]广东省开平市中心医院肾内科,广东开平529300

出　　处：《广东医科大学学报》2022年第6期687-690,共4页Journal of Guangdong Medical University

基　　金：江门市医疗卫生科技计划项目(2021YL10006)。

摘　　要：目的了解高通量透析(HFHD)联合Supra-HFR血滤吸附对维持性血液透析患者甲状旁腺素(PTH)、β2-微球蛋白(β2-MG)的清除效果。方法60例维持性血液透析患者随机采用HFHD(HFHD组)、血液透析联合Supra-HFR(HD+HFR组)和HFHD联合Supra-HFR(HFHD+HFR组)治疗6个月,比较3组患者治疗前后PTH、β2-MG、C反应蛋白(CRP)水平及临床症状(体力、食欲、睡眠、皮肤瘙痒)变化。结果3组患者治疗后PTH、β2-MG、CRP水平及临床症状评分显著降低,其中HFHD+HFR组更明显(P<0.05或0.01)。结论HFHD联合Supra-HFR可提高维持性血液透析患者PTH、β2-MG、CRP清除效果,减轻临床症状。Objective To observe the effect of high-flux hemodialysis(HFHD)and Supra-HFR on parathyroid hormone(PTH)andβ2-microglobulin(β2-MG)removal in maintenance hemodialysis(MHD)patients.Methods Sixty MHD patients were randomly treated with HFHD(HFHD group),hemodialysis plus Supra-HFR(HD+HFR group),or HFHD plus Supra-HFR(HFHD+HFR group)for 6 months.Levels of PTH,β2-MG and C-reactive protein(CRP),and clinical symptoms(physical strength,appetite,sleep,pruritus)were compared among 3 groups before and after treatment.Results Levels of PTH,β2-MG and CRP,and symptom scores were decreased in 3 groups posttreatment, especially in HFHD+HFR group (P<0.01 or 0.05). Conclusion HFHD plus Supra-HFR can improve the removal of PTH, β2-MG and CRP, and alleviate clinical symptoms in MHD patients.

关 键 词：高通量透析 Supra-HFR 维持性血液透析 

分 类 号：R692.5[医药卫生—泌尿科学]