中药诱导间充质干细胞成骨分化信号通路的研究进展  

Progress on Traditional Chinese Medicine-induced osteogenic differentiation signaling pathways of mesenchymal stem cells

作　　者：黄泽宇 梁艳芳 曾今诚 邱贤秀 HUANG Ze-yu;LIANG Yan-fang;ZENG Jin-cheng;QIU Xian-xiu(Dongguan Key Laboratory of Medical Bioactive Molecular Developmental and Translational Research,Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics,Guangdong Medical University,Dongguan 523808,China;School of Medical Technology,Guangdong Medical University,Dongguan 523808,China;Department of Pathology,Marina Bay Central Hospital of Dongguan/Affiliated Dongguan Hospital of Jinan University,Dongguan 523900,China;School of Basic Medicine,Guangdong Medical University,Dongguan 523808,China)

机构地区：[1]广东医科大学东莞市医学活性分子开发与转化重点实验室,广东省医学分子诊断重点实验室,广东东莞523808 [2]广东医科大学医学技术学院,广东东莞523808 [3]东莞市滨海湾中心医院/暨南大学附属东莞医院病理科,广东东莞523900 [4]广东医科大学基础医学院,广东东莞523808

出　　处：《广东医科大学学报》2022年第6期706-711,共6页Journal of Guangdong Medical University

基　　金：东莞市社会发展科技项目(20211800904532);广东省基础与应用基础研究基金项目(2021B1515140066);广东省省级大学生创新创业训练计划项目(S202110571058);广东省科技创新战略专项资金(大学生科技创新培育)项目(pdjh2022b0221)。

摘　　要：间充质干细胞(MSCs)来源于中胚层,具有自我更新、修复机体系统和多向分化潜能的细胞。近年来已筛选出许多诱导MSCs成骨分化的中药单体。该文总结了中药诱导MSCs成骨分化作用及其相关信号通路。Mesenchymal stem cells(MSCs)derive from mesoderm and have the potential of self-renewal and multidirectional differentiation.Recently,many monomers of traditional Chinese medicine(TCM)have been screened to induce the osteogenic differentiation of MSCs.This article summarizes the role and related signaling pathways of TCM in the osteogenic differentiation induction of MSCs.

关 键 词：中药 间充质干细胞 成骨分化 信号通路 

分 类 号：R932[医药卫生—生药学]