阿托伐他汀钙联合氯沙坦治疗老年高血压患者的效果  

Effects of Atorvastatin calcium combined with Losartan on elderly patients with hypertension

作　　者：陈晓琪 CHEN Xiaoqi(General Internal Medicine of Jiangsu Zhongshan Cadre Sanatorium,Nanjing 210014 Jiangsu,China)

机构地区：[1]江苏省钟山干部疗养院普内科,江苏南京210014

出　　处：《中国民康医学》2022年第22期36-39,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察阿托伐他汀钙联合氯沙坦治疗老年高血压患者的效果。方法:选取2020年12月至2021年12月该院收治的78例老年高血压患者进行前瞻性研究,按随机数字表法将其分为对照组与研究组各39例。对照组采用氯沙坦钾胶囊治疗,研究组在对照组基础上联合阿托伐他汀钙片治疗,比较两组治疗前后血压[收缩压(SBP)、舒张压(DBP)]水平、动脉硬化相关指标[斑块面积、颈动脉内中膜厚度(IMT)]水平、血脂指标[高密度脂蛋白胆固醇(HDL-C)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)和三酰甘油(TG)]水平、临床疗效和不良反应发生率。结果:治疗后,两组DBP、SBP水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组斑块面积和IMT水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组HDL-C水平均高于治疗前,且研究组高于对照组,两组TC、LDL-C、TG水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);研究组治疗总有效率为97.44%(38/39),高于对照组的76.92%(31/39),差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:阿托伐他汀联合氯沙坦治疗老年高血压患者可提高治疗总有效率,改善血脂指标水平,降低血压和动脉硬化相关指标水平,其效果优于单纯氯沙坦治疗。Objective:To observe effects of Atorvastatin calcium combined with Losartan on elderly patients with hypertension.Methods:A prospective study was conducted on 78 elderly patients with hypertension admitted to the hospital from December 2020 to December 2021.They were divided into control group and study group according to the random number table method,39 cases in each.The control group was treated with Losartan potassium capsules,while the study group was treated with Atorvastatin calcium tablets on the basis of that of the control group.The levels of blood pressure[systolic blood pressure(SBP),diastolic blood pressure(DBP)],the atherosclerosis related index levels[plaque area,carotid intimamedia thickness(IMT)],the blood lipid index levels[high density lipoprotein cholesterol(HDL-C),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C)and triglyceride(TG)],the clinical efficacy,and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:After the treatment,the levels of DBP and SBP in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).The plaque area and the IMT level of the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of HDL-C in the two groups were higher than those before the treatment,and that in the study group was higher than that in the control group;the levels of TC,LDL-C and TG in the two groups were lower than those before the treatment,and those in the study group were lower than those in the control group;and the differences were statistically significant(P<0.05).The total effective rate of treatment in the study group was 97.44%(38/39),which was higher than 76.92%(31/39)in the control group,and the difference was statistically significant(P<0.05).However,the

关 键 词：阿托伐他汀钙 氯沙坦 老年 高血压 动脉硬化指标 血脂 血压 

分 类 号：R544.1[医药卫生—心血管疾病]