连续性肾脏替代疗法在重度急性有机磷农药中毒患者中的应用效果  

Effects of CRRT in treatment of patients with severe acute organophosphorus pesticide poisoning

作　　者：黄元林 陈建洪 HUANG Yuanlin;CHEN Jianhong(Emergency Department of Putian Medical District of No.900 Hospital of Joint Logistics Support Force,Putian 351100 Fujian,China)

机构地区：[1]联勤保障部队第九〇〇医院莆田医疗区急诊科,福建莆田351100

出　　处：《中国民康医学》2022年第22期63-65,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:观察连续性肾脏替代疗法(CRRT)在重度急性有机磷农药中毒(AOPP)患者中的应用效果。方法:选取2019年3月至2021年8月该院收治的80例急性重度有机磷农药中毒患者进行前瞻性研究,按照随机数字表法分为对照组和观察组各40例。两组均予以基础治疗,在此基础上对照组给予盐酸戊乙奎醚注射液治疗,观察组在对照组基础上联合CRRT治疗。比较两组疗效、临床相关指标[胆碱酯酶(ChE)复活时间、意识清醒时间、住院时间]水平、血清炎性因子[C反应蛋白(CRP)、白细胞介素-6(IL-6)、IL-8、肿瘤坏死因子-α(TNF-α)]水平,以及不良反应发生率。结果:观察组治疗总有效率为85.00%,明显高于对照组的62.50%,差异有统计学意义(P<0.05);观察组意识清醒时间、ChE复活时间、住院时间均短于对照组,差异有统计学意义(P<0.05);治疗后,两组CRP、IL-6、TNF-α、IL-8水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率为22.50%,明显低于对照组的45.00%,差异有统计学意义(P<0.05)。结论:CRRT联合盐酸戊乙奎醚注射液治疗重度AOPP患者可提高治疗总有效率,降低临床相关指标水平、炎性因子水平和不良反应发生率,优于单纯盐酸戊乙奎醚注射液治疗效果。Objective:To observe effects of continuous renal replacement therapy(CRRT)in treatment of patients with severe acute organophosphorus pesticide poisoning(AOPP).Methods:A prospective study was conducted on 80 patients with acute severe organophosphorus pesticide poisoning admitted to the hospital from March 2019 to August 2021.They were divided into control group and observation group according to the random number table method,40 cases in each.Both groups were given basic treatment.On this basis,the control group was treated with Penehyclidine hydrochloride injection,while the observation group was treated with CRRT on the basis of that of the control group.The efficacy,the clinical related indicator levels[cholinesterase(ChE)reactivation time,consciousness recovery time,hospitalization time],the serum inflammatory factor levels[C-reactive protein(CRP),interleukin-6(IL-6),IL-8,tumor necrosis factor-α(TNF-α)],and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the observation group was 85.00%,which was significantly higher than 62.50%in the control group,and the difference was statistically significant(P<0.05).The consciousness recovery time,the ChE reactivation time and the hospitalization time of the observation group were shorter than those of the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of CRP,IL-6,TNF-αand IL-8 in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The incidence of adverse reactions of the observation group was 22.50%,which was significantly lower than 45.00%in the control group,and the difference was statistically significant(P<0.05).Conclusions:CRRT combined with Penehyclidine hydrochloride injection in the treatment of the severe AOPP patients can improve the total effective rate of treatment,reduce the levels of cli

关 键 词：连续肾脏替代疗法 盐酸戊乙奎醚注射液 急性中毒 有机磷 不良反应 炎性因子 

分 类 号：R459.7[医药卫生—急诊医学]