孕康颗粒联合盐酸利托君片治疗反复性流产效果及对血清孕激素、可溶性白细胞抗原G影响  

Curative effect of Yunkang granule combined with ritodrine hydrochloride tablet for treating women with recurrent abortion and its influences on the levels of serum progesterone and soluble leukocyte antigen G

作　　者：沈玉秀[1] 张丽 王梦晓 邵帅 单英俏 韩在刚[1] SHEN Yuxiu;ZHANG Li;WANG Mengxiao;SHAO Shuai;SHAN Yingqiao;HAN Zaigang(Affiliated Hospital of Beihua University,Jilin Province,132000)

机构地区：[1]北华大学附属医院,吉林132000

出　　处：《中国计划生育学杂志》2022年第12期2724-2727,2732,共5页Chinese Journal of Family Planning

摘　　要：目的:探讨孕康颗粒联合盐酸利托君片治疗反复性流产(RA)效果及对血清雌孕激素水平、可溶性白细胞抗原G(sHLA-G)水平影响。方法:前瞻性选取2019年1月-2021年1月在本院确诊的RA患者78例,简单随机分组为观察组(n=39)和对照组(n=39)。对照组予以盐酸利托君片治疗,观察组在对照组基础上联合口服孕康颗粒,持续用药2周。比较两组临床疗效、中医证候评分、不良反应与保胎成功率,检测雌二醇(E2)和孕酮(P)、sHLA-G水平。结果:治疗2周后,观察组临床总有效率(94.9%)高于对照组(79.5%),中医证候评分阴道出血(1.23±0.45分)、腹部坠痛(1.08±0.14分)、腰背酸痛(2.54±0.49分)低于对照组(1.98±0.48分、1.34±0.16分、2.87±0.46分)(均P<0.05);两组治疗2周后E2、P和sHLA-G水平均高于治疗前,且观察组高于对照组(均P<0.05);治疗期间不良反应发生率观察组(10.3%)与对照组(7.7%)无差异(P>0.05),保胎成功率观察组(94.9%)与对照组(89.7%)无差异(P>0.05)。结论:孕康颗粒联合盐酸利托君片治疗RA疗效确切,可以降低血清激素水平,改善患者临床症状。Objective:To explore the curative effect of Y unkang granule combined with ritodrine hydrochloride tablet for treating women with recurrent abortion(RA)and its influences on the levels of serum progesterone and soluble leukocyte antigen G(sHLA-G)of these women.Methods:A prospective selection was performed on 78 women with confirmed RA between January 2019 and January 2021.According to simple random grouping method,these women were divided into observation group(n=39)and control group(n=39).The women in the control group were treated with ritodrine hydrochloride tablets for 2 weeks,while the women in the observation group were unkang granule combined with ritodrine hydrochloride tablet for 2 weeks.The clinical curative effect,the scores of TCM syndromes,the adverse reactions rate,and the rate of success fetus protection of the women were compared between the two groups.The levels of estradiol(E2),progesterone(P),and sHLA-G of the women in the two groups were detected.Results:After 2 weeks of treatment,the total effective rate(94.9%)of the women in the observation group was significantly higher than that(79.5%)of the women in the control group.The scores of vaginal bleeding(1.23±0.45 points),the abdominal fall pain(1.08±0.14 points),and the back soreness(2.54±0.49 points)of TCM syndrome of the women in the observation group were significantly lower than those(1.98±0.48 points,1.34±0.16 points,and 2.87±0.46 points)of the women in the control group(P<0.05).After 2 weeks of treatment,the levels of Ez,P,and sHLA-G of the.women in both groups had increased significantly,and which of the women in the observation group were significantly higher than those of the women in the control group(P<0.05).There were no significant differences in the incidence of adverse reactions(10.3%vs.7.7%)and the rate of success fetus protection(94.9%vs.89.7%)of the women during treatment between the two groups(P>0.05).Conclusion:The curative effect of Y unkang granule combined with ritodrine hydrochloride tablet for treating women with

关 键 词：反复性流产 孕康颗粒 盐酸利托君片 雌激素 孕激素 可溶性白细胞抗原G 临床疗效 

分 类 号：R714.21[医药卫生—妇产科学]