缺氧缺血性脑病新生儿血清CK-MB、cTnI水平与NABA评分的相关性  

Correlation between the serum creatine kinase isoenzyme and cardiac troponin levels of neonates with hypoxic ischemic encephalopathy and their neonatal behavioral neurological assessment score

作　　者：田鹏 张沥文 杨莎 TIAN Peng;ZHANG Liwen;YANG Sha(Nanchong Central Hospital/The Second Clinical Medical College of North Sichuan Medical College,Nanchong,Sichuan Province,637000)

机构地区：[1]四川省南充市中心医院/川北医学院第二临床医学院,637000

出　　处：《中国计划生育学杂志》2022年第12期2852-2855,共4页Chinese Journal of Family Planning

基　　金：四川省卫生健康委员会科研课题(16PJ207)。

摘　　要：目的:分析缺氧缺血性脑病(HIE)新生儿血清磷酸肌酸激酶同工酶(CK-MB)、心肌肌钙蛋白(cTnI)水平与新生儿神经行为测定量表(NBNA)评分的相关性。方法:收集2018年7月-2020年7月本院收治的60例HIE患儿临床资料为观察组,根据病情严重程度分为轻度组(n=20)、中度组(n=26)及重度组(n=14),同期分娩的足月新生儿60例为对照组,检测各组新生儿血清CK-MB、cTnI水平和NABA评分并分析其关系,受术者工作特征曲线(ROC)分析各指标诊断HIE效能。结果:观察组血清CK-MB(112.06±25.47 U/L)、cTnI(2.45±0.36 ng/L)水平高于对照组(54.17±16.38 U/L、0.10±0.04 ng/L),NABA评分(34.41±5.10分)低于对照组(39.89±7.23分),且观察组中轻度组、中度组、重度组血清CK-MB、cTnI水平依次升高,NABA评分依次降低(均P<0.05)。ROC曲线分析显示,血清CK-MB、cTnI水平与NABA评分联合检测诊断HIE的曲线下面积为0.904(0.812~0.997),敏感度(96.3%)及特异度(87.5%)均提高(均P<0.05);Spearman相关性分析显示,血清CK-MB、cTnI水平与NABA评分均呈负相关性(P<0.05)。结论:HIE患儿血清CK-MB、cTnI水平呈高表达,NABA评分呈低表达,3项指标可评估病情严重程度并预测HIE发生,血清CK-MB、cTnI水平与NABA评分均呈负相关性。Objective:To study the correlation between serum creatine kinase isoenzyme(CK-MB)and cardiac troponin(cTnI)levels of neonates with hypoxic ischemic encephalopathy(HIE)and their neonatal behavioral neurological as-sessment(NABA)score.Methods:The clinical data of 60 neonates with HIE(in observation group)were collected between July 2018 and July 2020.According to the severity of HIE,these neonates were divided into 3 groups,which included 20 neonates with mild HIE in group A,26 neonates with moderate HIE in group B,and 14 neonates with severe HIE in group C.Meanwhile,60 normal neonates were selected in control group during the same period.The levels of serum CK-MB and cTnI of the neonates in these groups were detected,and the correlation between which and the NABA score of the neonates was analyzed.Receiver operator characteristic(ROC)curve was used to analyze the efficacy of the levels of serum CK-MB and cTnI of the neonates for diagnosing their HIE.Results:The levels of serum CK-MB(112.06±25.47 U/L)and cTnI(2.45±0.36 ng/L)of the neonates in the observation group were significantly higher than those(54.17±16.38 U/L and 0.10±0.04 ng/L)of the neonates in the control group,and which of the neonates in group A,group B,and group C had increased gradually.The NABA score(34.41±5.10 points)of the neonates in the observation group was significantly lower than that(39.89±7.23 points)of the neonates in the control group,and which of the neonates in group A,group B,and group C had decreased gradually(all P<0.05).ROC curve analysis showed that the area under the curve,the sensitivity,and the specificity of the combined of the serum CK-MB and cTnI levels,and the NABA score of the neonates for diagnosing their HIE were 0.904(0.812-0.997),96.3%,and 87.5%,respectively,and which were significantly higher than those of the serum CK-MB and cTnI levels or the NABA score alone(P<0.05).Spearman correlation analysis showed that the serum CK-MB and cTnI levels of the neonates were negative correlated with their NABA score(P<0.05).Co

关 键 词：新生儿缺氧缺血性脑病 磷酸肌酸激酶同工酶 心肌肌钙蛋白 新生儿行为神经评分 相关性 

分 类 号：R722.1[医药卫生—儿科]