妊娠期糖尿病患者LPL基因多态性与胰岛素抵抗关系  

Correlation between LPL gene polymorphism of pregnant women with gestational diabetes mellitus and their insulin resistance

作　　者：李萌 刘俊汝 郑伟英[1] LI Meng;LIU Junru;ZHENG Weiying(Jinhua People's Hospital,Zhejiang Province,321000)

机构地区：[1]浙江省金华市人民医院,321000

出　　处：《中国计划生育学杂志》2022年第12期2870-2874,共5页Chinese Journal of Family Planning

基　　金：黑龙江省教育厅科研项目(2016-KYYWF-0607);金华市公共卫生及生殖健康项目(2021-4-219)。

摘　　要：目的:探讨LPL基因多态性与妊娠期糖尿病患者胰岛素抵抗的相关性。方法:选取2019年1月-2020年4月本院分娩的妊娠期糖尿病患者93例作为GDM组,同期分娩的健康产妇105例作为正常组,采用聚合酶链反应-限制性内切酶片段长度多态性分析法分析胎盘组织LPL Hind基因多态性,统计分析两组对象及子代空腹血糖(FBG)、血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、空腹胰岛素(FINS)、胰岛素抵抗指数(IR)、体质指数(BMI)以及胰岛素抵抗指数(IR)与LPL多态性的关系。结果:GDM组H+等位基因的频率(82.8%)高于正常组(64.8%),H+H+基因型患者TC、TG、HDL、LDL、FINS、BMI与非H+H+基因型患者存在差异(均P<0.05);GDM组组织中LPL Hind基因多态性与胰岛素抵抗指标呈正相关性;GDM组H+H+基因型产妇子代BMI、IR、FINS均高于非H+H+基因型产妇子代(均P<0.05)。结论:LPL基因多态性是妊娠糖尿病患者胰岛素抵抗有关,可能影响其子代胰岛素抵抗发生异常。Objective:To explore the correlation between LPL gene polymorphism of pregnant women with gestational diabetes mellitus(GDM)and their insulin resistance.Methods:93 pregnant women with GDM who wanted delivered in hospital were selected in study group from January 2019 to April 2020,and 105 healthy pregnant women were selected in control group during the same period.Polymerase chain reaction restriction endonuclease fragment length polymorphism analysis method(PCR RFLP)analysis was used to detect the LPL Hind gene polymorphism in the placental tissue of these women.The levels of fasting blood glucose(FBG)of the women and their offspring,the levels of serum total cholesterol(TC),triglyceride(TG),high density lipoprotein(HDL),low density lipoprotein(LDL),and fasting insulin(FINS)of the women,and the values of insulin resistance index(IR)and body mass index(BMI)of the women were statistically analyzed.The correlation between the IR value of the women and their LPL polymorphism was also analyzed.Results:The H+allele frequency(82.8%)of the women in the study group was significantly higher than that(64.8%)of the women in the control group.There were significant differences in the levels of TC,TG,HDL,LDL,and FINS,and the BMI value between the women with H+H+genotype and the women without H+H+genotype(all<0.05).There was a positive correlation between LPL Hind gene polymorphism of the women in the study group and their insulin resistance index.The values of BMI and IR,and the FINS level of the offspring of the women with H+H+genotypes in the study group were significantly higher than those of the offspring of the women without H+H+genotypes(P<0.05).Conclusion:LPL gene polymorphism is involved in the insulin resistance of the pregnant women with GDM,which is related to the insulin resistance of the offspring of these women.

关 键 词：妊娠期糖尿病 LPL基因多态性 胰岛素抵抗 脂类代谢 子代 

分 类 号：R714.256[医药卫生—妇产科学]