微量元素锌在对抗新型冠状病毒肺炎中的作用研究进展  

Research Progress on the Role of Trace Element Zinc in Fight Against Corona Virus Disease 2019

作　　者：李嘉媛 张若辰 黎婧怡 陈鹰 马钲斐 袁林喜 LI Jiayuan;ZHANG Ruochen;LI Jingyi;CHEN Ying;MA Zhengfei;YUAN Linxi(Department of Chemistry,School of Science,Xi′an Jiaotong-Liverpool University,Suzhou,Jiangsu 215123,China;Department of Biological Sciences,School of Science,Xi′an Jiaotong-Liverpool University,Suzhou,Jiangsu 215123,China;School of Pharmacy,Xi′an Jiaotong-Liverpool University,Suzhou,Jiangsu 215123,China;University of the West of England,Bristol BS161QY,UK;Department of Health and Environmental Sciences,School of Science,Xi′an Jiaotong-Liverpool University,Suzhou,Jiangsu 215123,China)

机构地区：[1]西交利物浦大学理学院化学系,江苏苏州215123 [2]西交利物浦大学理学院生物学系,江苏苏州215123 [3]西交利物浦大学药学院,江苏苏州215123 [4]西英格兰大学,布里斯托BS161QY [5]西交利物浦大学理学院健康与环境科学系,江苏苏州215123

出　　处：《肥料与健康》2022年第6期1-8,共8页Fertilizer & Health

基　　金：西交利物浦大学大学生暑期研究奖学金/SURF 2022153。

摘　　要：新型冠状病毒肺炎(COVID-19)是由新型冠状病毒SARS-CoV-2引起的疾病,在全球范围内大面积传播,严重威胁公众的健康。研究发现:COVID-19易感人群与缺锌人群存在显著的重合性;从机制上,微量元素锌具有抗病毒、调节免疫、抗炎等生理功能,存在潜在的预防或治疗COVID-19的作用。临床试验结果证实:单独使用锌补充剂对COVID-19的治疗可能无效,但锌结合羟氯喹(HCQ)、阿奇霉素(AZM)的三联疗法对COVID-19的早期治疗是有效的。值得尝试开展锌与其他COVID-19治疗试剂的联合给药治疗的临床研究。进一步开展锌盐阻断多蛋白加工和抑制病毒复制活性的试验研究,可为阐明锌盐在对抗COVID-19中的潜在作用提供机制参考。Corona virus disease 2019(COVID-19) is a disease caused by the new coronavirus SARS-CoV-2, which spreads widely around the world and seriously threatens public health. There is a significant overlap between the susceptible population of COVID-19 and the zinc-deficient population. In terms of mechanism, the trace element zinc has physiological functions such as antiviral, immune regulation, and anti-inflammatory, and has a potential role in preventing or treating COVID-19. The clinical trial results confirm that zinc supplementation alone may be ineffective for the treatment of COVID-19, but the triple therapy of zinc combined with hydroxychloroquine(HCQ) and azithromycin(AZM) is effective for the early treatment of COVID-19. It is worth trying to carry out a clinical study on the combined administration of zinc and other COVID-19 therapeutic agents. Further experimental studies on the activity of zinc salts to block polyprotein processing and inhibit viral replication can provide a mechanism reference for elucidating the potential role of zinc salts in combating COVID-19.

关 键 词：新型冠状病毒肺炎 锌 抗病毒 调节免疫 抗炎 研究进展 

分 类 号：R563.1[医药卫生—呼吸系统]