刀削法联合重组人干扰素α-2a皮损内注射治疗跖疣患者的疗效观察  

Observation of efficacy of knife-assisted resection combined with intralesional injection of recombinant human interferon α-2a in the treatment of patients with plantar warts

作　　者：窦小军 DOU Xiao-jun(Department of Laser Cosmetology,Jiangyan District Dermatology Prevention and Treatment Hospital,Taizhou 225500,China)

机构地区：[1]泰州市姜堰区皮肤病防治院激光美容科,225500

出　　处：《中国现代药物应用》2022年第22期149-152,共4页Chinese Journal of Modern Drug Application

摘　　要：目的观察刀削法联合重组人干扰素α-2a皮损内注射治疗跖疣的临床疗效。方法选取92例单发跖疣患者为研究对象,随机分为治疗组(48例)和对照组(44例)。对照组采用液氮冷冻治疗,治疗组采用刀削法联合重组人干扰素α-2a皮损内注射治疗。比较两组患者临床疗效、皮损完全消退所需治疗次数、复发率,分析两组患者不良反应发生情况。结果92例患者中共89例患者完成治疗及随访,其中治疗组47例,对照组42例。第1疗程结束时,治疗组治疗总有效率为95.74%,高于对照组的76.19%,差异有统计学意义(P<0.05)。治疗组皮损完全消退所需治疗次数为(5.00±1.56)次,明显少于对照组的(8.00±1.46)次,差异有统计学意义(t=9.334,P<0.05)。治疗结束后随访3个月,治疗组2例患者复发,复发率为4.26%(2/47);对照组8例患者复发,复发率为19.05%(8/42)。治疗组复发率明显低于对照组,差异有统计学意义(χ2=4.866,P<0.05)。两组不良反应均为轻中度,短期可恢复,呈一过性,且均未出现肝肾功能异常、骨髓抑制等严重系统性不良反应。结论刀削法联合重组人干扰素α-2a皮损内注射治疗跖疣临床疗效显著,复发率低,值得临床推广应用。Objective To observe the clinical efficacy of knife-assisted resection combined with intralesional injection of recombinant human interferonα-2a in the treatment of patients with plantar warts.Methods A total of 92 patients with single plantar wart were selected as the research subjects,and were randomly divided into a treatment group(48 cases)and a control group(44 cases).The control group was treated with liquid nitrogen cryotherapy,and the treatment group was treated with knife-assisted resection combined with intralesional injection of recombinant human interferonα-2a.The clinical efficacy,the number of treatments required for complete regression of lesions,and the recurrence rate were compared between the two groups,and the incidence of adverse reactions in the two groups was analyzed.Results Of the 92 patients,89 patients completed the treatment and follow-up,with 47 cases in the treatment group and 42 cases in the control group.At the end of the first course of treatment,the total effective rate of the treatment group was 95.74%,which was higher than 76.19%of the control group,and the difference was statistically significant(P<0.05).The number of treatments required for complete regression of lesions in the treatment group was(5.00±1.56)times,which was significantly less than(8.00±1.46)times in the control group,and the difference was statistically significant(t=9.334,P<0.05).Followed up for 3 months after the treatment,2 patients in the treatment group relapsed,and the recurrence rate was 4.26%(2/47);8 patients in the control group relapsed,and the relapse rate was 19.05%(8/42).The recurrence rate of the treatment group was significantly lower than that of the control group,and the difference was statistically significant(χ2=4.866,P<0.05).Adverse reactions in both groups were mild to moderate,recoverable in the short term and transient,and no serious systemic adverse reactions such as abnormal liver and kidney function and bone marrow suppression were observed in either group.Conclusion Knife-assiste

关 键 词：刀削法 重组人干扰素Α-2A 跖疣 

分 类 号：R752.51[医药卫生—皮肤病学与性病学]