咳嗽性哮喘患者应用复方鲜竹沥液联合布地奈德和孟鲁司特钠治疗的临床疗效及对炎性因子和肺功能的影响  

Effect of Compound Fresh Bamboo Leachate Combined with Budesonide and Montelukast Sodium on Inflammatory Factors and Lung Function in Patients with Cough Asthma

作　　者：张萱 ZHANG Xuan(Zhongyi Northeast International Hospital Co.,LTD.,Shenyang 110000,China)

机构地区：[1]中一·东北国际医院有限公司,辽宁沈阳110000

出　　处：《中国医药指南》2023年第1期140-142,共3页Guide of China Medicine

摘　　要：目的探讨采用复方鲜竹沥液+布地奈德+孟鲁司特钠对咳嗽性哮喘患者进行治疗后对临床疗效、炎性因子以及肺功能产生的影响。方法将我院2019年1月至2020年7月收治的112例咳嗽性哮喘患者采用数字奇偶法分组;治疗组(56例)采用复方鲜竹沥液+布地奈德+孟鲁司特钠展开治疗,对照组(56例)采用布地奈德+孟鲁司特钠展开治疗,就组间哮喘疗效、肺功能指标以及炎性因子指标展开对比。结果治疗组咳嗽性哮喘患者总有效率(96.43%)高于对照组(76.79%)(P<0.05);治疗前,治疗组FEV_(1)/FVC(72.59±5.49)%、FEV_(1)%pred(79.22±6.36)%、PEF%pred(80.25±6.57)%同对照组FEV_(1)/FVC(71.29±5.29)%、FEV_(1)%pred(77.15±5.49)%、PEF%pred(79.66±6.85)%比较,差异无统计学意义(P>0.05);治疗后,治疗组FEV_(1)/FVC(83.25±6.19)、FEV_(1)%pred(96.35±7.83)、PEF%pred(95.55±7.39)均高于对照组FEV_(1)/FVC(78.55±5.82)、FEV_(1)%pred(89.43±7.66)、PEF%pred(89.69±7.61)(P<0.05);治疗前,治疗组TGF-β_(1)(34.79±9.15)ng/L、IL-8(117.03±13.89)ng/L、IgE(1466.82±130.11)U/L、TNF-α(1137.53±97.41)ng/L同对照组TGF-β_(1)(35.08±8.69)ng/L、IL-8(116.22±14.33)ng/L、IgE(1448.61±125.29)U/L、TNF-α(1123.45±98.13)ng/L比较,差异无统计学意义(P>0.05);治疗后,治疗组除TGF-β_(1)(71.25±13.19)ng/L高于对照组TGF-β_(1)(53.12±12.09)ng/L之外,IL-8(54.59±9.76)ng/L、IgE(700.39±91.89)U/L、TNF-α(612.55±81.39)ng/L均低于对照组IL-8(73.19±10.29)ng/L、IgE(948.21±99.13)U/L、TNF-α(820.69±86.61)ng/L(P<0.05)。结论复方鲜竹沥液+布地奈德+孟鲁司特钠的有效应用可使咳嗽性哮喘患者获得可靠的疗效,且患者的肺功能与炎性因子均获得理想的改善,最终实现咳嗽性哮喘患者预后转归改善。Objective To investigate the effects of compound fresh bamboo leachate + budesonide + montelukast sodium on clinical efficacy,inflammatory factors and lung function of patients with cough asthma. Methods From January 2019 to July 2020, 112 patients with cough asthma admitted to our hospital were grouped by the numerical chi-square method;the treatment group(56 cases) was treated with compound fresh bamboo liquid + budesonide + montelukast sodium, and the control group(56 cases) was treated with budesonide + montelukast sodium, and the asthma efficacy, pulmonary function indexes and inflammatory factor indexes were compared between the groups. Results The curative effect of cough asthma patients in treatment group(96.43%) was significantly higher than that in control group(76.79%)(P<0.05). Before the treatment,FEV_(1)/FVC(72.59±5.49), FEV_(1)% pred(79.22±6.36) and PEF% pred(80.25±6.57) in the treatment group were the same as those in the control group(71.29±5.29), FEV_(1)% pred(77.15±5.49) and PEF% pred(79.66±6.85), there was no significant difference(P>0.05). After treatment,FEV_(1)/FVC(83.25±6.19), FEV_(1)% pred(96.35±7.83) and PEF% pred(95.55±7.39) in the treatment group were higher than those in the control group(78.55±5.82), FEV_(1)% pred(89.43±7.66) and PEF% pred(89.69±7.61)(P<0.05). Before the treatment, TGF-β_(1)(34.79±9.15) ng/L,IL-8(117.03±13.89) ng/L, IgE(1466.82±130.11) U/L, TNF-α(1137.53±97.41) ng/L in the treatment group were the same as those in the control group(35.08±8.69) ng/L, IL-8(116.22±14.33) ng/L, IgE(1448.61±125.29) U/L, TNF-α(1123.45±98.13) ng/L, there was no significant difference(P>0.05). After treatment, TGF-β_(1)(71.25±13.19) ng/L in treatment group was higher than that in control group(53.12±12.09) ng/L,IL-8(54.59±9.76) ng/L, IgE(700.39±91.89) U/L, TNF-α(612.55±81.39) ng/L were lower than IL-8(73.19±10.29) ng/L, IgE(948.21±99.13) U/L, TNF-α(820.69±86.61) ng/L of the control group(P<0.05). Conclusion The effective application of compound fresh bamboo l

关 键 词：咳嗽性哮喘 复方鲜竹沥液 布地奈德 孟鲁司特钠 炎性因子 肺功能 

分 类 号：R725.6[医药卫生—儿科]