羧甲淀粉钠联合补锌治疗小儿反复呼吸道感染合并支气管哮喘效果及对患儿免疫指标水平的影响  

Effect of Sodium Carboxymethyl Starch Combined with Zinc Supplementation in the Treatment of Children with Recurrent Respiratory Tract Infection Complicated with Bronchial Asthma and Its Influence on Levels of Immune Indexes

作　　者：陈竞建 周明建 CHEN Jingjian;ZHOU Mingjian(Ningde Municipal Hospital of Ningde Normal University,Ningde 352100,China;不详)

机构地区：[1]宁德师范学院附属宁德市医院,福建宁德352100

出　　处：《中外医学研究》2022年第34期63-67,共5页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探析羧甲淀粉钠联合补锌治疗在小儿反复呼吸道感染合并支气管哮喘中的应用效果。方法:选取2020年2月-2021年2月宁德师范学院附属宁德市医院108例反复呼吸道感染合并支气管哮喘患儿,根据治疗方式分为观察组(n=56)和对照组(n=52),对照组给予常规治疗,观察组在对照组基础上给予羧甲淀粉钠溶液和甘草锌颗粒进行治疗,对两组临床疗效、治疗前后疾病相关指标及免疫功能指标进行对比。结果:观察组治疗总有效率为96.43%,高于对照组的80.77%,差异有统计学意义(P<0.05)。两组治疗前疾病相关指标对比,差异均无统计学意义(P>0.05);观察组治疗后呼吸道感染频率、支气管哮喘发作时间、抗生素应用时间均优于对照组,差异均有统计学意义(P<0.05)。两组治疗前免疫功能指标对比,差异均无统计学意义(P>0.05);观察组治疗后免疫球蛋白G(IgG)、免疫球蛋白A(IgA)、免疫球蛋白M(IgM)、CD4^(+)及CD4^(+)/CD8^(+)均优于对照组,差异均有统计学意义(P<0.05),但两组治疗后CD8^(+)比较,差异无统计学意义(P>0.05)。结论:羧甲淀粉钠联合补锌治疗应用于小儿反复呼吸道感染合并支气管哮喘中,能有效改善患儿IgG、IgA、IgM、CD4^(+)及CD4^(+)/CD8^(+)等免疫功能指标,减少呼吸道感染次数、支气管哮喘发作时间、抗生素应用时间,且能有效提升治疗效果,值得进行临床推广。Objective:To explore the application effect of Sodium Carboxymethyl Starch combined with Zinc supplementation in the treatment of children with recurrent respiratory tract infection complicated with bronchial asthma.Method:From February 2020 to February 2021,108 children with recurrent respiratory tract infection complicated with bronchial asthma in Ningde Municipal Hospital of Ningde Normal University were divided into the observation group(n=56)and the control group(n=52)according to the treatment method.The control group was given routine treatment,and the observation group was treated with Sodium Carboxymethyl Starch combined with Glycyrrhizin Granules on the basis of the control group.Clinical efficacy,disease-related indexes and immune function indexes before and after treatment were compared between two groups.Result:The total effective rate of the observation group was 96.43%,which was higher than 80.77%of the control group,the difference was statistically significant(P<0.05).There were no significant differences in the disease-related indexes between two groups before treatment(P>0.05);the frequency of respiratory tract infection,bronchial asthma attack time and antibiotic application time in the observation group after treatment were better than those in the control group,the differences were statistically significant(P<0.05).There were no significant differences in the immune function indexes between two groups before treatment(P>0.05);the immunoglobulin G(IgG),immunoglobulin A(IgA),immunoglobulin M(IgM),CD4^(+)and CD4^(+)/CD8^(+)in the observation group after treatment were better than those in the control group,the differences were statistically significant(P<0.05),but there was no statistical significance in CD8^(+)between two groups after treatment(P>0.05).Conclusion:Sodium Carboxymethyl Starch combined with Zinc supplementation can effectively improve IgG,IgA,IgM,CD4^(+),CD4^(+)/CD8^(+)and other immune function indicators in children with recurrent respiratory tract infection complicated with bron

关 键 词：羧甲淀粉钠 补锌治疗 小儿反复呼吸道感染 支气管哮喘 免疫指标 

分 类 号：R725.6[医药卫生—儿科]