婴幼儿反复呼吸道感染与血清25羟维生素D水平及体外过敏原、总IgE的关系  

Relationship between recurrent respiratory tract infection and serum 25-hydroxyvitamin D level, vitro allergens, and total IgE in infants

作　　者：刘素琴 李燕[1] 王磊[2] 魏梦月 LIU Suqin;LI Yan;WANG Lei;WEI Mengyue(Department of Pediatrics,Yangzhou Women and Children Care Service Hospital Affiliated to Yangzhou University Medical College,Jiangsu Province,Yangzhou225002,China;Department of Child Healthcare,Yangzhou Women and Children Care Service Hospital Affiliated to Yangzhou University Medical College,Jiangsu Province,Yangzhou225002,China)

机构地区：[1]扬州大学医学院附属扬州市妇幼保健院儿科,江苏扬州225002 [2]扬州大学医学院附属扬州市妇幼保健院儿童保健科,江苏扬州225002

出　　处：《中国医药导报》2022年第35期88-91,共4页China Medical Herald

基　　金：江苏省扬州市科技计划-社会发展项目(YZ2020077);江苏省妇幼健康科研项目(F202019);中国疾病预防控制中心妇幼保健中心合生元母婴营养与健康研究项目(2017FYH005)。

摘　　要：目的探讨婴幼儿反复呼吸道感染(RRTI)与血清25羟维生素D[25-(OH)D]水平及体外过敏原、总免疫球蛋白E(IgE)的关系。方法选择2018年12月至2019年6月在扬州大学医学院附属扬州市妇幼保健院(以下简称“我院”)就诊的RRTI患儿100例作为观察组,另选择我院首次呼吸道感染年龄在3~18个月,随访至2周岁仍仅有一次呼吸道感染史的患儿100例为首次感染组;儿童保健科进行健康体检的婴幼儿100名为健康组;将首次感染组及健康组同时纳入对照组。比较各组25-(OH)D水平;比较观察组及对照组体外过敏原指标及总IgE;logistic回归分析婴幼儿RRTI的危险因素。结果观察组血清25-(OH)D水平低于对照组(P<0.01)。观察组血清25-(OH)D水平低于健康组、首次感染组(P<0.01)。观察组屋尘、鸡蛋白、牛奶、柏榆柳栎桦枫胡桃梧桐杨阳性率高于对照组(P<0.05或P<0.01)。两组总IgE水平分布比较,差异无统计学意义(P>0.05)。25-(OH)D是RRTI发生的保护因素(OR<1,P<0.05)。结论RRTI患儿血清25-(OH)D水平较低,25-(OH)D可能在RRTI的发生中起保护作用,RRTI患儿过敏原多个指标阳性率较高,但不能以体外过敏原阳性来预测患儿是否易发生RRTI。Objective To explore the relationship between 25-(OH)D level,vitro allergens,and total immunoglobulin E(IgE)in recurrent respiratory tract infections(RRTI)in infants.Methods From December 2018 to June 2019,100 infants with RRTI who admitted to Yangzhou Women and Children Care Service Hospital Affiliated to Yangzhou University Medical College(hereinafter referred to as“our hospital”)were selected as observation group,another 100 infants with the first respiratory tract infection aged from 3 to 18 months in our hospital,who were followed up to two years old and still had only one history of respiratory tract infection as first infection group;100 infants and toddlers who underwent physical examination in Department of Child Healthcare as healthy group.The first infection group and healthy group were included in control group.The 25-(OH)D levels were compared among all groups;vitro allergen indexes and total IgE were compared between observation group and control group;the risk factors of RRTI in infants were analyzed by logistic regression.Results The level of serum 25-(OH)D in observation group was lower than that in control group(P<0.01).The level of serum 25-(OH)D in observation group was lower than that in healthy group and first infection group(P<0.01).The positive rates of house dust,egg white,milk,and oak birch maple walnut sycamore poplar in observation group were higher than those in control group(P<0.05 or P<0.01).There was no significant difference in total IgE between two groups(P>0.05).25-(OH)D was a protective factor for RRTI(OR<1,P<0.05).Conclusion The serum 25-(OH)D level in RRTI children is low,and 25-(OH)D may play a protective role in the occurrence of RRTI.The positive rate of allergens in RRTI children is high,but the vitro allergen positive can not be used to predict whether the children are prone to RRTI.

关 键 词：婴幼儿 反复呼吸道感染 25羟维生素D 体外过敏原 总免疫球蛋白E 

分 类 号：R725.6[医药卫生—儿科]