维生素D与乙型肝炎病毒感染相关肝组织损伤的研究进展  

Advances in the study of vitamin D and liver tissue damage associated with hepatitis B virus infection

作　　者：李娜 马臻[2] LI Na;MA Zhen(Graduate School,Inner Mongolia Medical University,Inner Mongolia Autonomous Region,Hohhot010050,China;Affiliated Hospital of Inner Mongolia Medical University,Inner Mongolia Autonomous Region,Hohhot010050,China)

机构地区：[1]内蒙古医科大学研究生院,内蒙古呼和浩特010050 [2]内蒙古医科大学附属医院,内蒙古呼和浩特010050

出　　处：《中国医药导报》2022年第35期49-52,共4页China Medical Herald

基　　金：内蒙古自治区卫生健康科技计划项目(202202176)。

摘　　要：乙型病毒性肝炎严重危害全人类健康,其相关肝纤维化、肝硬化、肝细胞癌也是临床治疗的重点和难点。近年来,越来越多的研究证明,维生素D缺乏与乙型病毒性肝炎所致的肝组织损伤关系密切。维生素D可通过调节肝星状细胞、免疫细胞;激活多种通路;维持线粒体正常结构、功能和氧化能力等途径减缓肝损伤进程。维生素D受体表达与肝损伤分期关系密切。抗病毒治疗过程中补充维生素D可降低乙型肝炎患者肝损伤,改善患者预后。Viral hepatitis B is a serious health hazard for all human beings,and hepatitis B-related liver fibrosis,cirrhosis,and hepatocellular carcinoma are also the focus and difficulty of clinical treatment.In recent years,an increasing number of studies have demonstrated the close relationship between vitamin D deficiency and liver tissue damage due to viral hepatitis B.Vitamin D may slow down the process of liver injury by regulating hepatic stellate cells,immune cells;activating multiple pathways;and maintaining normal mitochondrial structure,function and oxidative capacity.Vitamin D receptor expression is closely related to the staging of liver injury.Vitamin D supplementation during antiviral therapy may reduce liver injury and improve prognosis in patients with hepatitis B.

关 键 词：维生素D 乙型肝炎 肝纤维化 肝细胞癌 核苷(酸)类似物 

分 类 号：R512.6[医药卫生—内科学]