心力衰竭不同生物标志物与中医证型的关系进展  

Advances in the relationship between different biomarkers and traditional Chinese medicine syndrome types of heart failure

作　　者：郭亚楠[1] 王晓燕 高嘉良[3] 何红涛[1] 王思洲[1] 王艳炜 耿彬[1] 赵天资 GUO Yanan;WANG Xiaoyan;GAO Jialiang;HE Hongtao;WANG Sizhou;WANG Yanwei;GENG Bin;ZHAO Tianzi(Department of Cardiology,Hebei Province Hospital of Traditional Chinese Medicine,Hebei Province,Shijiazhuang 050011,China;Department of Cardiology,Wangjing Hospital,China Academy of Chinese Medical Sciences,Beijing 100102,China;Department of Cardiology,Guang’anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China)

机构地区：[1]河北省中医院心内科,河北石家庄050011 [2]中国中医科学院望京医院心内科,北京100102 [3]中国中医科学院广安门医院心内科,北京100053

出　　处：《中国医药导报》2022年第35期32-35,44,共5页China Medical Herald

基　　金：国家自然科学基金青年科学基金项目(82004287);河北省省级科技计划-重点研发计划项目(182777215);河北省中医药管理局中医药类科研计划课题(2019007)。

摘　　要：心力衰竭是一种复杂的心血管终末期临床综合征,临床应用的传统生物标志物有B型利钠肽、N末端B型利钠肽原、心肌肌钙蛋白,以及传统炎症生物标志物。炎症在心力衰竭的发生和进展中起着关键作用,因此,近年来已经研究了几种新型炎症生物标志物用于诊断、预后和治疗评估。此外,代谢组等“组学”生物标志物形象反映了心力衰竭不同中医证型的代谢模式,为客观辨证论治提供依据。本文归纳了传统生物标志物、新型炎症生物标志物、代谢组学生物标志物在心力衰竭病证诊断、预后方面的研究进展;概述了心力衰竭不同生物标志物与中医证型的关系。以期为筛选出更多可用于中医辨证论治过程的生物标志物打下基础,从而进一步提高心力衰竭中医证候的客观标准化辨识水平。Heart failure is a complex clinical syndrome of end-stage cardiovascular disease.The classical and traditional biomarkers in clinical application include brain natriuretic peptide,N-terminal proBNP,cardiac troponin and traditional biomarkers of inflammation.Inflammation plays a key role in the occurrence and progression of heart failure,therefore,several novel biomarkers have been developed in recent years for diagnosis,prognosis,and treatment evaluation.The metabonomics and other“omics”biomarkers could reflect the metabonomic patterns of different traditional Chinese medicine syndrome types of heart failure,and supply a basis for the objective syndrome differentiation and treatment.This paper summarise the research progress of traditional biomarkers,new inflammatory biomarkers and metabolic biomarkers in the diagnosis and prognosis of heart failure.The relationship between different biomarkers and traditional Chinese medicine syndromes of heart failure was summarized.In order to lay a foundation for screening more biomarkers that can be used in the process of traditional Chinese medicine syndrome differentiation and treatment,so as to further improve the objective standard identification level of traditional Chinese medicine syndromes of heart failure.

关 键 词：心力衰竭 生物标志物 证型 代谢组学 

分 类 号：R54[医药卫生—心血管疾病]