基于数据挖掘分析头颈部恶性肿瘤放射性口咽炎的中药外治处方规律  

Reaserch on prescription rule of external treatment of Chinese medicine for radiopharyngitis of head and neck malignancy based on data mining

作　　者：龚璐天 宋卓 许云[1] 郭欣煜 付力 王晶惠 GONG Lutian;SONG Zhuo;XU Yun;GUO Xinyu;FU Li;WANG Jinghui(Department of Oncology,Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing100091,China)

机构地区：[1]中国中医科学院西苑医院肿瘤科,北京100091

出　　处：《中国医药导报》2022年第34期103-107,共5页China Medical Herald

基　　金：国家自然科学基金资助项目(82074414);中国中医科学院育苗基金培育专项(ZZ11-069)。

摘　　要：目的基于数据挖掘分析头颈部恶性肿瘤放射性口咽炎的中药外治处方规律。方法检索中国知网、万方数据知识服务平台、中国生物医学文献服务系统、维普中文期刊数据服务平台从建库至2021年11月的头颈部肿瘤放射性口咽炎中药外治文献,使用SPSS Modeler 18.0、SPSS Statistics 25.0软件,以用药频次、性味归经、药物关联规则及聚类方法进行统计分析。结果最终筛选文献65篇,66首处方,125味中药,累计使用频数474次。使用频率>30%的中药为甘草、金银花、生地黄、麦冬、薄荷。四气主要为寒、微寒、平,五味多为苦、甘、辛,归经多为肺、肝、胃、心经。功效以清热及补虚类居多。组方规律得出25个关联规则,复杂网络分析发现甘草、金银花、生地黄、麦冬、玄参链接较强,聚类分析得到6大聚类。结论中药外治放射性口咽炎多分期论治,初期祛邪清热,中后期滋阴生津,三焦同治,扶正祛邪同步,其用药规律可以为临床提供实践参考。Objective To explore the prescription rule of external treatment of Chinese medicine for radiopharyngitis of head and neck malignancy based on data mining.Methods The external treatment literatures of Chinese medicine for radiopharyngitis of head and neck malignancy from the inception to November 2021 on CNKI,Wanfang,CBM and VIP Data were retrieved.SPSS Modeler 18.0 and SPSS Statistics 25.0 software were used for statistical analysis by frequency of medication,nature,flavour and channel tropism,drug association rules and clustering method.Results Sixty-five literatures,66 prescriptions,125 traditional Chinese medicines were finally screened,and the cumulative use frequency was 474 times.The Chinese medicine used more than 30%frequently were Glycyrrhizae Radix Et Rhizoma,Lonicerae Japonicae Flos,Rehmanniae Radix,Ophiopogonis Radix and Menthae Haplocalycis Herba.The four nature of drugs were mainly cold,slightly cold,and flat.The five flavors were mostly bitter,sweet,and pungent.The channel tropism were mainly lung,liver,stomach,and heart channels.Most of the effects were heat clearing and deficiency tonifying.Twenty-five association rules were obtained from the medication rule.Complex network analysis found that Glycyrrhizae Radix Et Rhizoma,Lonicerae Japonicae Flos,Rehmanniae Radix,Ophiopogonis Radix and Scrophulariae Radix had strong links.Six clusters were obtained by cluster analysis.Conclusion The external treatment of radiopharyngitis with Chinese medicine is mostly by stages.Removing pathogenic factors and clearing away heat in the early stage,nourishing yin and promoting fluid production in the middle and late stages.Simultaneous treatment of sanjiao,synchronization of strengthening vital qi to eliminate pathogenic evil.The medication rule can provide practical reference for clinical practice.

关 键 词：放射性口咽炎 数据挖掘 外治方药 组方规律 聚类分析 

分 类 号：R273[医药卫生—中西医结合]